Mouse anti-Human Platelet Factor 4 Monoclonal Antibody | anti-PF4V1 antibody
Anti-Human Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b)
Gene Names
PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
Reactivity
Human
Applications
Western Blot, ELISA
Synonyms
Platelet Factor 4, Antibody; Anti-Human Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b); Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b); Anti-Human Platelet Factor IV/Heparin; anti-PF4V1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2bκ
Clone Number
KKO
Specificity
This antibody is specific for Human Platelet Factor IV /heparin complexes.
Form/Format
Purified; IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography). For maximum recovery of contents, spin down tube before use.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
104
Applicable Applications for anti-PF4V1 antibody
WB (Western Blot), ELISA
Immunogen
Human Factor IV purified from the supernatant of thrombin activated platelets.
Presentation
Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascetic fluid via Protein G Chromatography). For maximum recovery of contents, spin down tube before use.
Preparation and Storage
For all formats, store at 4°C. For long term storage (Purified, Biotin, HRPO), aliquot and freeze unused portion at -20°C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Related Product Information for anti-PF4V1 antibody
Description: Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity.
Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FcgammaIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation. (clone KKO), unlike (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT.
Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FcgammaIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation. (clone KKO), unlike (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
platelet factor 4
NCBI Official Synonym Full Names
platelet factor 4 variant 1
NCBI Official Symbol
PF4V1
NCBI Official Synonym Symbols
PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
NCBI Protein Information
platelet factor 4 variant; PF4alt; PF4var1; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like)
UniProt Protein Name
Platelet factor 4 variant
UniProt Gene Name
PF4V1
UniProt Synonym Gene Names
CXCL4V1; SCYB4V1
UniProt Entry Name
PF4V_HUMAN
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Product Notes
The PF4V1 pf4v1 (Catalog #AAA74215) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Platelet Factor 4 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PF4V1 pf4v1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Platelet Factor 4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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