Mouse anti-Rat PLSCR1 Monoclonal Antibody | anti-PLSCR1 antibody

Anti-Rt PLSCR1 Ascites

Cat. Num. AAA129164

• Reactivity: Rat
• Applications: Flow Cytometry, Functional Assay, Immunocytochemistry, Western Blot, Immunoprecipitation
• Purity: Ascitic fluid is diluted with storage buffer to final antibody concentration 5mg/ml.
• Synonyms: PLSCR1, Antibody; Anti-Rt PLSCR1 Ascites; PL scramblase 1; Phospholipid scramblase 1; phospholipid scramblase 1; anti-PLSCR1 antibody

• Host: Mouse
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: Mouse IgG2a
• Clone Number: 13A6 [TEC-23]
• Specificity: The antibody 13A6 [TEC-23] binds to an intracellular epitope of rat Phospholipid Scramblase 1 (PLSCR1), an 37-49kDa protein, accelerating bidirectional movement of plasma membrane phospholipids under conditions of elevated calcium.
• Purity/Purification: Ascitic fluid is diluted with storage buffer to final antibody concentration 5mg/ml.
• Form/Format: Ascites. Undiluted ascitic fuild with 15mM sodium azide

• Applicable Applications for anti-PLSCR1 antibody: FCM/FACS (Flow Cytometry), ICC (Immunocytochemistry), WB (Western Blot), IP (Immunoprecipitation)
• Immunogen: Pooled lipid raft fraction isolated from RBL-2H3 cells
• Preparation and Storage: Store at 2-8 degree C. Do not freeze. Do not use after expiration date stamped on the label.

Related Product Information for anti-PLSCR1 antibody

PLSCR1 (Phospholipid Scramblase 1) is a multiply palmitoylated endofacial plasma membrane protein containing several SH3 and WW domain binding motives. In the plasma membrane, PLSCR1 plays a role in transbilayer lipid redistributions and signal transduction. Nonpalmitoylated PLSCR1, however, is able to be transported into the nucleus and bind DNA. PLSCR1 potentiates the antiviral activity of interferon and its expression is highly induced by interferons and growth factors.

References

*Smrž D, Lebduška P, Dráberová L, Korb J, Dráber P: Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis. J Biol Chem. 2008 Apr 18;283(16):10904-18., URL: https://www.ncbi.nlm.nih.gov/pubmed/18281686ordin
*Pastorelli C, Veiga J, Charles N, Voignier E, Moussu H, Monteiro RC, Benhamou M: IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. J Biol Chem. 2001 Jun 8;276(23):20407-12. Epub 2001 Mar 20., URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgidb=p,*Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ: Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. Cancer Res. 2002 Jan 15;62(2):397-402., URL: https://www.ncbi.nlm.nih.gov/pubmed/11809687dopt=,*Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH: Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J Virol. 2004 Sep;78(17):8983-93., URL: https://www.ncbi.nlm.nih.gov/pubmed/15308695dopt=

NCBI and Uniprot Product Information

• NCBI GI #: 17105346
• NCBI GeneID: 117540
• NCBI Accession #: NP_476542.1
• NCBI GenBank Nucleotide #: NM_057194.1
• UniProt Accession #: P58195
• Molecular Weight: 36,711 Da
• NCBI Official Full Name: phospholipid scramblase 1
• NCBI Official Synonym Full Names: phospholipid scramblase 1
• NCBI Official Symbol: Plscr1
• NCBI Protein Information: phospholipid scramblase 1; PL scramblase 1; phospholipid scramblase 2; ca(2+)-dependent phospholipid scramblase 1
• UniProt Protein Name: Phospholipid scramblase 1
• UniProt Gene Name: Plscr1
• UniProt Synonym Gene Names: PL scramblase 1
• UniProt Entry Name: PLS1_RAT