IHC (Immunohiostchemistry)
(Immunohistochemistry of Prion protein in paraffin-embedded Human breast cancer tissue using Prion Protein Rabbit mAb at dilution 1/20)
Prion Protein Monoclonal Antibody | anti-PRNP antibody
Prion Protein Rabbit mAb
Gene Names
PRNP; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Affinity Purified
Synonyms
Prion Protein, Antibody; Prion Protein Rabbit mAb; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; anti-PRNP antibody
Host
Recombinant Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
S03-2E2
Purity/Purification
Affinity Purified
Form/Format
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration
0.3mg/ml (varies by lot)
Applicable Applications for anti-PRNP antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide of human Prion protein PrP
Conjugation
Unconjugated
Modification
Unmodification
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry of Prion protein in paraffin-embedded Human breast cancer tissue using Prion Protein Rabbit mAb at dilution 1/20)
IHC (Immunohiostchemistry)
(Immunohistochemistry of Prion protein in paraffin-embedded Human breast cancer tissue using Prion Protein Rabbit mAb at dilution 1/20)
WB (Western Blot)
(Western blot detection of Prion protein in Rat Brain and Mouse Brain lysates using Prion Protein Rabbit mAb (1:1000 diluted).Predicted band size:28kDa.Observed band size:28kDa.)
WB (Western Blot)
(Western blot detection of Prion protein in Rat Brain and Mouse Brain lysates using Prion Protein Rabbit mAb (1:1000 diluted).Predicted band size:28kDa.Observed band size:28kDa.)
Related Product Information for anti-PRNP antibody
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Product Categories/Family for anti-PRNP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33kDa
NCBI Official Full Name
major prion protein preproprotein
NCBI Official Synonym Full Names
prion protein
NCBI Official Symbol
PRNP
NCBI Official Synonym Symbols
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
NCBI Protein Information
alternative prion protein; major prion protein; CD230 antigen; prion-related protein
UniProt Protein Name
Major prion protein
UniProt Gene Name
PRNP
UniProt Synonym Gene Names
PRIP; PRP; PrP
UniProt Entry Name
PRIO_HUMAN
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Product Notes
The PRNP prnp (Catalog #AAA314442) is an Antibody produced from Recombinant Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Prion Protein Rabbit mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Prion Protein can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the PRNP prnp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Prion Protein, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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