WB (Western Blot)
(PTPN11 Antibody western blot analysis in mouse brian tissue lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).)
Mouse anti-Human, mouse PTPN11 Monoclonal Antibody | anti-PTPN11 antibody
PTPN11 Antibody
Gene Names
PTPN11; CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3
Reactivity
Human, mouse
Applications
ELISA, Western Blot
Synonyms
PTPN11, Antibody; PTPN11 Antibody; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C; SHPTP2; anti-PTPN11 antibody
Host
Mouse
Reactivity
Human, mouse
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
246CT9.8.2
Specificity
This PTPN11 monoclonal antibody is generated from mouse immunized with PTPN11 recombinant protein.
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Sequence Length
593
Applicable Applications for anti-PTPN11 antibody
ELISA, WB (Western Blot)
Calculated MW
68436
Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Tissue location
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20° C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(PTPN11 Antibody western blot analysis in mouse brian tissue lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).)
WB (Western Blot)
(PTPN11 Antibody western blot analysis in mouse brian tissue lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).)
WB (Western Blot)
(PTPN11 Antibody western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).)
WB (Western Blot)
(PTPN11 Antibody western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).)
Related Product Information for anti-PTPN11 antibody
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains two tandem Src
homology-2 domains, which function as phospho-tyrosine binding
domains and mediate the interaction of this PTP with its
substrates. This PTP is widely expressed in most tissues and plays
a regulatory role in various cell signaling events that are
important for a diversity of cell functions, such as mitogenic
activation, metabolic control, transcription regulation, and cell
migration. Mutations in this gene are a cause of Noonan syndrome as
well as acute myeloid leukemia.
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains two tandem Src
homology-2 domains, which function as phospho-tyrosine binding
domains and mediate the interaction of this PTP with its
substrates. This PTP is widely expressed in most tissues and plays
a regulatory role in various cell signaling events that are
important for a diversity of cell functions, such as mitogenic
activation, metabolic control, transcription regulation, and cell
migration. Mutations in this gene are a cause of Noonan syndrome as
well as acute myeloid leukemia.
Product Categories/Family for anti-PTPN11 antibody
References
Yang, X., et al. Mol. Cell. Biol. 30(22):5306-5317(2010)
Kikkawa, N., et al. Br. J. Cancer 103(6):877-884(2010)
Meng, S., et al. J Mol Cell Biol 2(4):223-230(2010)
Demir, K., et al. Turk. J. Pediatr. 52(3):321-324(2010)
Tang, C., et al. Zhongguo Fei Ai Za Zhi 13(2):98-101(2010)
Kikkawa, N., et al. Br. J. Cancer 103(6):877-884(2010)
Meng, S., et al. J Mol Cell Biol 2(4):223-230(2010)
Demir, K., et al. Turk. J. Pediatr. 52(3):321-324(2010)
Tang, C., et al. Zhongguo Fei Ai Za Zhi 13(2):98-101(2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 11 isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 11
NCBI Official Symbol
PTPN11
NCBI Official Synonym Symbols
CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 11
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 11
UniProt Gene Name
PTPN11
UniProt Synonym Gene Names
PTP2C; SHPTP2; PTP-1D; PTP-2C; SHP-2; Shp2
UniProt Entry Name
PTN11_HUMAN
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Product Notes
The PTPN11 ptpn11 (Catalog #AAA283508) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PTPN11 Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN11 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PTPN11 ptpn11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN11, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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