Mouse anti-Human S100A12 Monoclonal Antibody | anti-S100A12 antibody
S100A12, Human, mAb 203
Reactivity
Human
Applications
Western Blot
Synonyms
S100A12, Antibody; S100A12, Human, mAb 203; Protein S100-A12; CGRP; Calcium-binding protein in amniotic fluid 1; CAAF1; Calgranulin-C; CAGC; Extracellular newly identified RAGE-binding protein; EN-RAGE; Migration inhibitory factor-related protein 6; MRP-6; p6; Neutrophil S100 protein; S100 calcium-binding protein A12; Gene name: S100A12; anti-S100A12 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2a
Clone Number
203
Form/Format
Quantities >500 ug will be send without preservative and carrier free. Quantities <500 ug will be send with preservative and carrier. exact formulation can be found on the datasheet.
Applicable Applications for anti-S100A12 antibody
WB (Western Blot), IA (Immunoassay)
Immunogen
Recombinant S100A12
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
Related Product Information for anti-S100A12 antibody
The monoclonal antibody clone 203 recognizes S100 calcium-binding protein A12 (S100A12). The antibody does not cross-react with family members S100A7, S100A8 and S100A9 and S100A8/A9 heterodimers. S100A12, also known as calgranulin C, is a member of the S100 protein family. To date, the family consists of 22 members. S100 proteins are low molecular weight calcium binding proteins. The proteins consist of 2 calcium binding EF-hands located on the termini flanked by hydrophobic hinge regions. Calcium ions acts as a global second messenger involved in the regulation of many aspects of cell function. S100 proteins are involved in sensing and transforming calcium signals to downstream cellular responses. S100 proteins are located in the cytoplasm and/or nucleus of a wide range of cell types and involved in the regulation of cellular processes such as cell cycle progression and differentiation and inflammatory responses. Several S100 members have been found to act as cytokines in inflammation, particularly in autoimmune skin conditions such as psoriasis. S100A12 is involved in calcium-dependent signal transduction pathways and has regulatory effects on cytoskeletal components thereby modulating neutrophil activities. Studies have shown that S100A12 might have potential as a biomarker for arthritis since their levels correlate with disease activity and are able to predict relapse and response to anti-inflammatory therapy. Unfortunately, studying the biology of S100A12 and other calgranulins is challenging due to its tendency to form complex homodimer, heterodimer and heterotetramers structures.
Product Categories/Family for anti-S100A12 antibody
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Product Notes
The S100A12 (Catalog #AAA77818) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The S100A12, Human, mAb 203 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's S100A12 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IA (Immunoassay). Researchers should empirically determine the suitability of the S100A12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "S100A12, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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