Mouse anti-Human SERBP1 Monoclonal Antibody | anti-SERBP1 antibody

SERBP1/PAI-RBP1

Cat. Num. AAA215398

• Gene Names: SERBP1; CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: SERBP1, Antibody; SERBP1/PAI-RBP1; CGI 55; CHD3IP; Chromodomain helicase DNA binding protein 3 interacting protein; HABP4L; PAI1 RNA-binding protein 1; PAIRBP1; Plasminogen activator inhibitor 1 RNA binding protein; SERPINE1 mRNA binding protein 1; anti-SERBP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: SERBP1/3509
• Specificity: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 408

• Applicable Applications for anti-SERBP1 antibody: WB (Western Blot), IHC (Immunohistochemistry)
• Immunogen: Recombinant fragment of Human SERBP1 protein (around aa3-139) (exact sequence is proprietary)
• Cellular Localization: Cytoplasmand Nucleus. Also found in Perinuclear regions.
• Hu-chromosome Location: 1p31.3
• Positive Control: K562 or PC3 cells. Human kidney or Bladder tissue (IHC).
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

WB (Western Blot)

(Western Blot Analysis of K562 and PC3 cell lysate using SERBP1 Mouse Monoclonal Antibody (SERBP1/3509).)

Application Data

(Analysis of Protein Array containing more than 19,000 full-length human proteins using SERBP1 Mouse Monoclonal Antibody (SERBP1/3509). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)

SDS-PAGE

(SDS-PAGE Analysis Purified SERBP1 Mouse Monoclonal Antibody (SERBP1/3509). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Urothelial Carcinoma stained with SERBP1 Mouse Monoclonal Antibody (SERBP1/3509).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Urothelial Carcinoma stained with SERBP1 Mouse Monoclonal Antibody (SERBP1/3509).)

References

Heaton, J.H., et al. 2001. Journal of Biological Chemistry 276: 3341-3347.

NCBI and Uniprot Product Information

• NCBI GI #: 66346679
• NCBI GeneID: 26135
• NCBI Accession #: NP_001018077
• NCBI GenBank Nucleotide #: NP_001018077.1
• UniProt Accession #: Q8NC51
• Molecular Weight: 60kDa
• NCBI Official Full Name: plasminogen activator inhibitor 1 RNA-binding protein isoform 1
• NCBI Official Synonym Full Names: SERPINE1 mRNA binding protein 1
• NCBI Official Symbol: SERBP1
• NCBI Official Synonym Symbols: CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1
• NCBI Protein Information: plasminogen activator inhibitor 1 RNA-binding protein
• UniProt Protein Name: Plasminogen activator inhibitor 1 RNA-binding protein
• UniProt Gene Name: SERBP1
• UniProt Synonym Gene Names: PAIRBP1; PAI-RBP1
• UniProt Entry Name: PAIRB_HUMAN