SDS-PAGE
(SDS PAGE for Sibrotuzumab)
anti-Human Sibrotuzumab Monoclonal Antibody | anti-FAP antibody
Research Grade Sibrotuzumab
Gene Names
FAP; FAPA; DPPIV
Reactivity
Human
Purity
>95%; Protein A or G purified from cell culture supernatant.
Synonyms
Sibrotuzumab, Antibody; Research Grade Sibrotuzumab; BIBH1; Surface-expressed protease; Gelatine degradation protease FAP; Integral membrane serine protease; Dipeptidyl peptidase FAP; Seprase; FAP; Post-proline cleaving enzyme; APCE; SIMP; FAPalpha; 170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Serine integral membrane protease; Prolyl endopeptidase FAP; anti-FAP antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1-kappa
Purity/Purification
>95%; Protein A or G purified from cell culture supernatant.
Form/Format
Liquid. PBS buffer, pH7.4
Concentration
1mg/ml (varies by lot)
Host Species
Humanized
CAS
216669-97-5
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at +4 degree C short term (1-2 weeks). Store at -20 degree C 12 months. Store at -80 degree C long term.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
SDS-PAGE
(SDS PAGE for Sibrotuzumab)
SDS-PAGE
(SDS PAGE for Sibrotuzumab)
Bioactivity
(Detects Human FAP/FAPalpha in direct ELISAs.)
Bioactivity
(Detects Human FAP/FAPalpha in direct ELISAs.)
Product Categories/Family for anti-FAP antibody
References
Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer, PMID: 12624517
Population pharmacokinetics of sibrotuzumab, a novel therapeutic monoclonal antibody, in cancer patients, PMID: 14707493
Reprograming Carcinoma Associated Fibroblasts by microRNAs, PMID: 29210650
Tumors and their microenvironments: tilling the soil. Commentary re: A. M. Scott et al., A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 9: 1639-1647, 2003, PMID: 12738710
Gateways to clinical trials, PMID: 15071612
Population pharmacokinetics of sibrotuzumab, a novel therapeutic monoclonal antibody, in cancer patients, PMID: 14707493
Reprograming Carcinoma Associated Fibroblasts by microRNAs, PMID: 29210650
Tumors and their microenvironments: tilling the soil. Commentary re: A. M. Scott et al., A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 9: 1639-1647, 2003, PMID: 12738710
Gateways to clinical trials, PMID: 15071612
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
87,713 Da
NCBI Official Full Name
seprase
NCBI Official Synonym Full Names
fibroblast activation protein, alpha
NCBI Official Symbol
FAP
NCBI Official Synonym Symbols
FAPA; DPPIV
NCBI Protein Information
seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase
UniProt Protein Name
Seprase
UniProt Gene Name
FAP
UniProt Entry Name
SEPR_HUMAN
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Product Notes
The FAP fap (Catalog #AAA120094) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Research Grade Sibrotuzumab reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Sibrotuzumab, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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