IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human lymph node stained with TIM3 Mouse Monoclonal Antibody (TIM3/4030).)
Mouse anti-Human TIM3/HAVCR2/CD366 Monoclonal Antibody | anti-HAVCR2 antibody
TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Mouse Monoclonal Antibody [Clone TIM3/4030]
Gene Names
HAVCR2; TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
TIM3/HAVCR2/CD366, Antibody; TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Mouse Monoclonal Antibody [Clone TIM3/4030]; TIM3/HAVCR2/CD366 (Effector T-Cell Marker); CD366; HAVR2; Hepatitis A virus cellular receptor 2 (HAVCR2); Kidney injury molecule 3 (KIM3); T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD3; anti-HAVCR2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse/IgG2b, kappa
Clone Number
TIM3/4030
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-HAVCR2 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)
Cellular Localization
Cell Surface
Positive Control
HepG2 or Daudi cells. Human tonsil, lymph node or spleen.
Hu-chromosome Location
5q33.3
Unigene
710500
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human lymph node stained with TIM3 Mouse Monoclonal Antibody (TIM3/4030).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human lymph node stained with TIM3 Mouse Monoclonal Antibody (TIM3/4030).)
Related Product Information for anti-HAVCR2 antibody
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
301
NCBI Official Full Name
Hepatitis A virus cellular receptor 2
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 2
NCBI Official Symbol
HAVCR2
NCBI Official Synonym Symbols
TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
NCBI Protein Information
hepatitis A virus cellular receptor 2; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglo
UniProt Protein Name
Hepatitis A virus cellular receptor 2
UniProt Gene Name
HAVCR2
UniProt Synonym Gene Names
TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3
UniProt Entry Name
HAVR2_HUMAN
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Product Notes
The HAVCR2 havcr2 (Catalog #AAA216010) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Mouse Monoclonal Antibody [Clone TIM3/4030] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TIM3/HAVCR2/CD366 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the HAVCR2 havcr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIM3/HAVCR2/CD366, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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