Application Data
Mouse TNF-a Monoclonal Antibody | anti-TNF-a antibody
mAb anti-Human TNF-a
Gene Names
TNF; DIF; TNFA; TNFSF2; TNF-alpha
Reactivity
Human. Other species not tested
Purity
Protein G affinity purified
Synonyms
TNF-a, Antibody; mAb anti-Human TNF-a; Tumor Necrosis Factor Alpha (TNF-alpha); Tumor Necrosis Factor Alpha (TNF-a); Mouse monoclonal antibody to human Tumor Necrosis Factor alpha (TNF-alpha); anti-TNF-a antibody
Host
Mouse
Reactivity
Human. Other species not tested
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
C2A7
Specificity
This antibody recognizes recombinant human TNF-?. Reactivity with natural TNF-? is not tested.
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.0
Sequence Length
233
Target Protein
Human TNF-alpha
Immunogen
Purified recombinant human TNF-alpha
Myeloma
Sp2/0-Ag14
Light Chain
Kappa
Reconstitution
Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area
Cytokine, inflammation
Preparation and Storage
Store at -20 degree C
Application Data
Application Data
Related Product Information for anti-TNF-a antibody
Tumor Necrosis Factor alpha (TNF-?) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-? regulation is associated with its ability to trigger multiple signalling pathways through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-? not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-? hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-?, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-? therapy has been used for treatment of rheumatoid arthritis.
Product Categories/Family for anti-TNF-a antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
TNF-alpha
NCBI Official Synonym Full Names
tumor necrosis factor
NCBI Official Symbol
TNF
NCBI Official Synonym Symbols
DIF; TNFA; TNFSF2; TNF-alpha
NCBI Protein Information
tumor necrosis factor; APC1 protein; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; cachectin; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
UniProt Protein Name
Tumor necrosis factor
UniProt Gene Name
TNF
UniProt Entry Name
TNFA_HUMAN
Similar Products
Product Notes
The TNF-a tnf (Catalog #AAA77918) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mAb anti-Human TNF-a reacts with Human. Other species not tested and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "TNF-a, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.