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Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using VEGI Rabbit Recombinant Monoclonal Antibody (VEGI/2052R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Rabbit TNFS15/VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody | anti-TNFS15 antibody
TNFS15/VEGI (Vascular Endothelial Growth Inhibitor)
Gene Names
TNFSF15; TL1; TL1A; VEGI; TNLG1B; VEGI192A
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
TNFS15/VEGI (Vascular Endothelial Growth Inhibitor), Antibody; TNFS15/VEGI (Vascular Endothelial Growth Inhibitor); TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A; anti-TNFS15 antibody
Host
Rabbit
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG
Clone Number
VEGI/2052R
Specificity
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Form/Format
200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
192
Applicable Applications for anti-TNFS15 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant full-length human VEGI protein
Cellular Localization
Secreted and Cell Surface
Hu-chromosome Location
9q32
Positive Control
Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using VEGI Rabbit Recombinant Monoclonal Antibody (VEGI/2052R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using VEGI Rabbit Recombinant Monoclonal Antibody (VEGI/2052R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified VEGI Rabbit Monoclonal Antibody (VEGI /2052R).)
SDS_PAGE
(SDS-PAGE Analysis Purified VEGI Rabbit Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).)
References
Zhai, Y., et al. 1999. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J. 13: 181-189. Zhai, Y., et al. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. Int. J. Cancer 82: 131-136. 5. Parr C, Gan CH, Watkins G, Jiang WG. Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients. Angiogenesis.2006; 9(2):73-81.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
22kDa
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
NCBI Official Synonym Full Names
TNF superfamily member 15
NCBI Official Symbol
TNFSF15
NCBI Official Synonym Symbols
TL1; TL1A; VEGI; TNLG1B; VEGI192A
NCBI Protein Information
tumor necrosis factor ligand superfamily member 15
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 15
UniProt Gene Name
TNFSF15
UniProt Synonym Gene Names
TL1; VEGI
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Product Notes
The TNFS15 tnfsf15 (Catalog #AAA214623) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNFS15/VEGI (Vascular Endothelial Growth Inhibitor) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's TNFS15/VEGI (Vascular Endothelial Growth Inhibitor) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TNFS15 tnfsf15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFS15/VEGI (Vascular Endothelial Growth Inhibitor), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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