Mouse anti-Human Transferrin receptor 1 Monoclonal Antibody | anti-TFRC antibody
Transferrin receptor 1, Human, mAb 3B8 2A1
Reactivity
Human
Applications
Western Blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Synonyms
Transferrin receptor 1, Antibody; Transferrin receptor 1, Human, mAb 3B8 2A1; anti-TFRC antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
3B8 2A1
Form/Format
1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Sequence Length
760
Applicable Applications for anti-TFRC antibody
WB (Western Blot), IP (Immunoprecipitation), IA (Immunoassay), FCM/FACS (Flow Cytometry)
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
Related Product Information for anti-TFRC antibody
Product Description: Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2.
References
1. Vogt, T et al; Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 2003, 101: 2008 2. Johnson, M et al; Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004, 104: 4287
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Symbol
TFRC
NCBI Protein Information
transferrin receptor protein 1; transferrin receptor 1
Similar Products
Product Notes
The TFRC (Catalog #AAA77762) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Transferrin receptor 1, Human, mAb 3B8 2A1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Transferrin receptor 1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IP (Immunoprecipitation), IA (Immunoassay), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the TFRC for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transferrin receptor 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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