Mouse TROPONIN I Monoclonal Antibody | anti-TNNI3 antibody
MOUSE ANTI HUMAN TROPONIN I (CARDIAC/PHOSPHORYLATED)
Gene Names
TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
Reactivity
Bovine, Cat, Dog, Goat, Pig, RatN.B Antibody reactivity and working conditions may vary between species.
Applications
Western Blot, ELISA
Synonyms
TROPONIN I, Antibody; MOUSE ANTI HUMAN TROPONIN I (CARDIAC/PHOSPHORYLATED); TNNC1; anti-TNNI3 antibody
Host
Mouse
Reactivity
Bovine, Cat, Dog, Goat, Pig, Rat
N.B Antibody reactivity and working conditions may vary between species.
N.B Antibody reactivity and working conditions may vary between species.
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
1G11
Form/Format
Purified IgG - liquid
Concentration
IgG concentration 1 mg/ml (varies by lot)
Sequence Length
210
Applicable Applications for anti-TNNI3 antibody
WB (Western Blot), ELISA
Perservative Stabilisers
0.09% Sodium Azide
Immunogen
Phosphorylated form of human cardiac Troponin I.
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0 mouse myeloma cell line.
Buffer Solution
Phosphate buffered saline
Target Species
Human
Preparation
Purified IgG prepared by affinity chromatography on protein A from tissue culture supernatant
Preparation and Storage
Store at 4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Related Product Information for anti-TNNI3 antibody
Mouse anti Human Troponin I (Cardiac/Phosphorylated) antibody, clone 1G11 recognizes the phosphorylated form of human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Phosphorylation of cTnI results in changes in the activity and function of Troponin. One possible form of phosphorylation is by Protein kinase A. Protein kinase A phosphorylation of serine 22 and serine 23 reduces calcium sensitivity of Troponin and leads to an acceleration in relaxation. Changes in cTnI phosphorylation have been reported in failing hearts. Mouse anti Human Troponin I (Cardiac/Phosphorylated) antibody, clone 1G11 recognizes free cTnI and cTnI in complex with other Troponin components. It does not cross-react with skeletal Troponin I.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I type 3 (cardiac)
NCBI Official Symbol
TNNI3
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
NCBI Protein Information
troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive)
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Gene Name
TNNI3
UniProt Synonym Gene Names
TNNC1
UniProt Entry Name
TNNI3_HUMAN
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Product Notes
The TNNI3 tnni3 (Catalog #AAA49541) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MOUSE ANTI HUMAN TROPONIN I (CARDIAC/PHOSPHORYLATED) reacts with Bovine, Cat, Dog, Goat, Pig, Rat N.B Antibody reactivity and working conditions may vary between species. and may cross-react with other species as described in the data sheet. AAA Biotech's TROPONIN I can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TNNI3 tnni3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TROPONIN I, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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