SDS-PAGE
(SDS PAGE for Ulocuplumab)
anti-Human Ulocuplumab Monoclonal Antibody | anti-CXCR4 antibody
Research Grade Ulocuplumab
Gene Names
CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E
Reactivity
Human
Purity
>95% by SDS-PAGE.Purification: Protein A or G purified from cell culture supernatant.
Synonyms
Ulocuplumab, Antibody; Research Grade Ulocuplumab; BMS-936564; MDX-1338; MDX1338; Stromal cell-derived factor 1 receptor; LCR1; HM89; LPS-associated protein 3; LAP-3; CXC-R4; CXCR-4; SDF-1 receptor; CD184; NPYRL; LESTR; Fusin; FB22; C-X-C chemokine receptor type 4; CXCR4; Lipopolysaccharide-associated protein 3; Leukocyte-derived seven transmembrane domain receptor; anti-CXCR4 antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG4-kappa
Purity/Purification
>95% by SDS-PAGE.
Purification: Protein A or G purified from cell culture supernatant.
Purification: Protein A or G purified from cell culture supernatant.
Form/Format
Liquid. 0.01M PBS, pH 7.4.
Concentration
1.59 mg/ml (varies by lot)
Expression system
XtenCHO
Host Species
Human
CAS
1375830-34-4
Target
Stromal cell-derived factor 1 receptor, LCR1, HM89, LPS-associated protein 3, LAP-3, CXC-R4, CXCR-4, SDF-1 receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-C chemokine receptor type 4, CXCR4, Lipopolysaccharide-associated protein 3, Leukocyte-derived seven transmembrane domain receptor
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at -20°C 12 months. Store at -80°C long term.
Store at -20°C 12 months. Store at -80°C long term.
SDS-PAGE
(SDS PAGE for Ulocuplumab)
SDS-PAGE
(SDS PAGE for Ulocuplumab)
Related Product Information for anti-CXCR4 antibody
Ulocuplumab (BMS-936564) is a first-in-class fully human IgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. The CXCR4/CXCL12 (SDF-1) axis has been known for many years as a critical regulator of tumor proliferation, cell, as well as migration into and out of the bone marrow.
Product Categories/Family for anti-CXCR4 antibody
References
What is new in the treatment of Waldenstrom macroglobulinemia?, PMID: 31591468
Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions, PMID: 32758634
Immunotherapy for small-cell lung cancer: emerging evidence, PMID: 26882955
Ulocuplumab (BMS-936564/MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway, PMID: 26646452
A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma, PMID: 31672767
Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions, PMID: 32758634
Immunotherapy for small-cell lung cancer: emerging evidence, PMID: 26882955
Ulocuplumab (BMS-936564/MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway, PMID: 26646452
A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma, PMID: 31672767
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,746 Da
NCBI Official Full Name
C-X-C chemokine receptor type 4 isoform a
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 4
NCBI Official Symbol
CXCR4
NCBI Official Synonym Symbols
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E
NCBI Protein Information
C-X-C chemokine receptor type 4; fusin; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-seg
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Gene Name
CXCR4
UniProt Synonym Gene Names
CXC-R4; CXCR-4; LESTR
UniProt Entry Name
CXCR4_HUMAN
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Product Notes
The CXCR4 cxcr4 (Catalog #AAA120087) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Research Grade Ulocuplumab reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Ulocuplumab, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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