FGF-23 active protein
Recombinant Mouse FGF-23
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & HPLC analyses
Synonyms
FGF-23; N/A; Recombinant Mouse FGF-23; Fibroblast Growth Factor 23; FGF-23 active protein
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE & HPLC analyses
Form/Format
Lyophilized
Sequence
MYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTI YSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC K FRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLAR RNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VS CSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV
Sequence Length
228
Expressed in
E.coli
Biological Activity
Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 ug/ml, in the presence of murine Klotho and heparin.
Endotoxin Level
< 0.1 ng/ug of protein (<1EU/ug)
Reconstitution
Centriguge the vial before opening. Reconstitute in water to a concentration of 0.1-1.0 mg/m. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it recommended to further dilute in a buffer containing a carrier protein (example: 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Preparation and Storage
The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C.
Related Product Information for FGF-23 active protein
The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues.
Product Categories/Family for FGF-23 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25.5 kDa
NCBI Official Full Name
fibroblast growth factor 23
NCBI Official Synonym Full Names
fibroblast growth factor 23
NCBI Official Symbol
Fgf23
NCBI Protein Information
fibroblast growth factor 23; FGF-23
UniProt Protein Name
Fibroblast growth factor 23
UniProt Gene Name
Fgf23
UniProt Synonym Gene Names
FGF-23
UniProt Entry Name
FGF23_MOUSE
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Product Notes
The FGF-23 fgf23 (Catalog #AAA79235) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Mouse FGF-23 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTI YSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC K FRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLAR RNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VS CSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV. It is sometimes possible for the material contained within the vial of "FGF-23, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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