Mouse TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Antibody | anti-TIMP2 antibody

TIMP2 (Tissue Inhibitor of Metalloproteinase 2)

Cat. Num. AAA215218

• Gene Names: TIMP2; DDC8; CSC-21K
• Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Zebrafish
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: TIMP2 (Tissue Inhibitor of Metalloproteinase 2); N/A; Metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP-2; TIMP2; Tissue Inhibitor of Metalloproteinase 2; anti-TIMP2 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Zebrafish
• Isotype: IgG1, kappa
• Clone Number: rTIMP2/2335
• Specificity: It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 220

• Applicable Applications for anti-TIMP2 antibody: IHC (Immunohistochemistry)
• Positive Control: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.
• Immunogen: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)
• Cellular Localization: Cytoplasm and Cell Surface
• Hu-chromosome Location: 17q25
• Antibody Type: Recombinant Mouse Monoclonal Antibody
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified TIMP2 Mouse Recombinant Monoclonal Antibody (rTIMP2/2335). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Placenta stained with TIMP2 Mouse Recombinant Monoclonal Antibody (rTIMP2/2335).)

References

1. Jeffery et al. 2009. Histopathology. 54(7):820-8. 2. Murray et al. 1998. Gut. 43(6):791-7.

NCBI and Uniprot Product Information

• NCBI GI #: 4507511
• NCBI GeneID: 7077
• NCBI Accession #: NP_003246.1
• NCBI GenBank Nucleotide #: NP_003246.1
• UniProt Accession #: P16035
• Molecular Weight: 21kDa
• NCBI Official Full Name: metalloproteinase inhibitor 2
• NCBI Official Synonym Full Names: TIMP metallopeptidase inhibitor 2
• NCBI Official Symbol: TIMP2
• NCBI Official Synonym Symbols: DDC8; CSC-21K
• NCBI Protein Information: metalloproteinase inhibitor 2
• UniProt Protein Name: Metalloproteinase inhibitor 2
• UniProt Gene Name: TIMP2
• UniProt Synonym Gene Names: TIMP-2
• UniProt Entry Name: TIMP2_HUMAN