FCM/FACS (Flow Cytometry)
(Flow cytometric analysis of GAK cells were stained using GPR48 antibody.)
Mouse GPR48 (Lgr4) Antibody
GPR48 (Lgr4) Antibody
Reactivity
Human, Mouse, Rat
Synonyms
GPR48 (Lgr4); N/A; GPR48 (Lgr4) Antibody; BNMD17; G protein coupled receptor 48; G-protein coupled receptor 48; GPR48; Leucine-rich repeat-containing G protein-coupled receptor 4; Leucine-rich repeat-containing G-protein coupled receptor 4; LGR4; LGR4_HUMAN; anti-GPR48 (Lgr4) antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
GPR48 Antibody detects endogenous levels of total GPR48.
Preparation and Storage
Store at -20 °C. Stable for 12 months from date of receipt.
FCM/FACS (Flow Cytometry)
(Flow cytometric analysis of GAK cells were stained using GPR48 antibody.)
FCM/FACS (Flow Cytometry)
(Flow cytometric analysis of GAK cells were stained using GPR48 antibody.)
IF (Immunofluorescence)
(GPR48 antibody staining GAK cells by IF/ICC. (endogeneous) Overexpress GPR48-GFP fusion protein in 293T cells, and incubated with primary GPR48 antibody(red).)
IF (Immunofluorescence)
(GPR48 antibody staining GAK cells by IF/ICC. (endogeneous) Overexpress GPR48-GFP fusion protein in 293T cells, and incubated with primary GPR48 antibody(red).)
Related Product Information for anti-GPR48 (Lgr4) antibody
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).
NCBI and Uniprot Product Information
UniProt Accession #
Molecular Weight
110 kDa
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Product Notes
The GPR48 (Lgr4) (Catalog #AAA62494) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GPR48 (Lgr4) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "GPR48 (Lgr4), Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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