Application Data
(Structure of T8270-10.)
6,6'-Trehalose Dimycolate Accessory Reagent
6,6'-Trehalose Dimycolate (Cord-Factor, TDM)
Applications
Immunoadjuvant
Purity
Purified by Thin layer chromatography. >97%. Single spot
Synonyms
6,6'-Trehalose Dimycolate; N/A; 6,6'-Trehalose Dimycolate (Cord-Factor, TDM); 6,6'-Trehalose Dimycolate accessory reagent
Host
Mycobacterium bovis, Bacillus Calmette Guerin
Purity/Purification
Purified by Thin layer chromatography. >97%. Single spot
Form/Format
Supplied as a lyophilized powder
Applicable Applications for 6,6'-Trehalose Dimycolate accessory reagent
Immunoadjuvant
Application Notes
Immunoadjuvant:
100ug-1mg TDM/ml
Optimal dilutions to be determined by the researcher.
100ug-1mg TDM/ml
Optimal dilutions to be determined by the researcher.
Endotoxin
<10e-4 EU/ug (LAL)
Molecular Formula
C130H 250O15C2H6
Important Note
This product as supplied is intented for research use only.
Solubility (50mg/ml)
Chloroform: methanol: water (90:10:1)
Specific Rotation
+32 to +35 degree C, c=1
Quality Control
MALDI-TOF
Preparation and Storage
Store at -20 degree C in the dark. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Application Data
(Structure of T8270-10.)
Application Data
(Structure of T8270-10.)
Application Data
(Structure of AAA14806. 6'-Dicorynomycolate; 6,6' DiO-mycolyl,a -a, trehalos; sTDM, TDCM; Trehalose-6 ; sTDCM; Synthetic cord factor.)
Application Data
(Structure of AAA14806. 6'-Dicorynomycolate; 6,6' DiO-mycolyl,a -a, trehalos; sTDM, TDCM; Trehalose-6 ; sTDCM; Synthetic cord factor.)
Related Product Information for 6,6'-Trehalose Dimycolate accessory reagent
6,6'-Trehalose Dimycolate (Cord Factor, source: Mycobacterium bovis, Bacillus Calmette Guerin) 6,6'-dimycoloyl-a-D-trehalose (Mycobacterium bovis, BCG) is used as an immunoadjuvant for the induction and non-specific stimulation of antibody production against unrelated antigens. This results in an increased host resistance against infections and cancer, in the potentiation of vaccine immunogeneticity and in an increase of DNA vaccination efficacy.
6'6-Trehalose dimycolate (TDM) exhibits strong immunomodulatory effects, greatly enhancing the efficacy of DNA vaccination, shown to facilitate single-shot prime-boost DNA vaccines (3). TDM from M. bovis has a lower granulomatogenic activity as compared to TDM from M. tuberculosis (5). Preinjection of TDM followed by antigen injection triggers elevated antibody production (2). TDM stimulates macrophages, enhances non-specific immune responses and stimulates the antigen-presenting ability (7, 10). TDM Exhibits anti-tumor activity (2). TDM induces the production of both Th1-type and Th2-type cytokines (IFN-alpha, IFN-beta, IFN-gamma, IL-4, IL-6, IL-10, IL-12, TNF-alpha) as well as chemokines (MCP-1, MIP-1alpha, IL-8) (4, 6, 8, 9,11). TDM upregulates MHC class II expression on macrophages and causes expansion of Th1 cells (9). TDM is non-toxic on organisms and serves as protection against killing from macrophages. TDM becomes antigenic and highly toxic, when exposed to lipid surfaces.
6'6-Trehalose dimycolate (TDM) exhibits strong immunomodulatory effects, greatly enhancing the efficacy of DNA vaccination, shown to facilitate single-shot prime-boost DNA vaccines (3). TDM from M. bovis has a lower granulomatogenic activity as compared to TDM from M. tuberculosis (5). Preinjection of TDM followed by antigen injection triggers elevated antibody production (2). TDM stimulates macrophages, enhances non-specific immune responses and stimulates the antigen-presenting ability (7, 10). TDM Exhibits anti-tumor activity (2). TDM induces the production of both Th1-type and Th2-type cytokines (IFN-alpha, IFN-beta, IFN-gamma, IL-4, IL-6, IL-10, IL-12, TNF-alpha) as well as chemokines (MCP-1, MIP-1alpha, IL-8) (4, 6, 8, 9,11). TDM upregulates MHC class II expression on macrophages and causes expansion of Th1 cells (9). TDM is non-toxic on organisms and serves as protection against killing from macrophages. TDM becomes antigenic and highly toxic, when exposed to lipid surfaces.
Product Categories/Family for 6,6'-Trehalose Dimycolate accessory reagent
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Product Notes
The 6,6'-Trehalose Dimycolate (Catalog #AAA14806) is an Accessory Reagent produced from Mycobacterium bovis, Bacillus Calmette Guerin and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's 6,6'-Trehalose Dimycolate can be used in a range of immunoassay formats including, but not limited to, Immunoadjuvant. Immunoadjuvant: 100ug-1mg TDM/ml Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the 6,6'-Trehalose Dimycolate for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "6,6'-Trehalose Dimycolate, Accessory Reagent" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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