SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
Metalloendopeptidase OMA1, mitochondrial (OMA1) Recombinant Protein | OMA1 recombinant protein
Recombinant Human Metalloendopeptidase OMA1, mitochondrial (OMA1)(Active)
Gene Names
OMA1; DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik
Purity
Greater than 90% as determined by SDS-PAGE.
Synonyms
Metalloendopeptidase OMA1, mitochondrial (OMA1); N/A; Recombinant Human Metalloendopeptidase OMA1, mitochondrial (OMA1)(Active); Metalloprotease-related protein 1; OMA1 recombinant protein
Host
E coli (in vitro)
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
Lyophilized powder. Lyophilized from 20 mM Tris-HCl, 0.15 M NaCl, 0.05% FOS12, 6% Trehalose, pH 8.0
Sequence
HVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS
Sequence Length
14-524aa; Full Length
Species
Homo sapiens (Human)
Tag
N-terminal 6xHis-SUMO-tagged
Transmembrane Domain
1TM
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized OMA1 at 5ug/ml can bind human BZW2, the EC50 of human BZM2 is 45.42-72.22ug/ml.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Preparation and Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
Bioactivity
Bioactivity
Related Product Information for OMA1 recombinant protein
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.
Product Categories/Family for OMA1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,744 Da
NCBI Official Full Name
metalloendopeptidase OMA1, mitochondrial
NCBI Official Synonym Full Names
OMA1 zinc metallopeptidase
NCBI Official Symbol
OMA1
NCBI Official Synonym Symbols
DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik
NCBI Protein Information
metalloendopeptidase OMA1, mitochondrial
UniProt Protein Name
Metalloendopeptidase OMA1, mitochondrial
UniProt Gene Name
OMA1
UniProt Synonym Gene Names
MPRP1; MPRP-1
UniProt Entry Name
OMA1_HUMAN
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Product Notes
The OMA1 oma1 (Catalog #AAA279390) is a Recombinant Protein produced from E coli (in vitro) and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: HVFFRFNSLS NWRKCNTLAS TSRGCHQVQV NHIVNKYQGL GVNQCDRWSF LPGNFHFYST FNNKRTGGLS STKSKEIWRI TSKCTVWNDA FSRQLLIKEV TAVPSLSVLH PLSPASIRAI RNFHTSPRFQ AAPVPLLLMI LKPVQKLFAI IVGRGIRKWW QALPPNKKEV VKENIRKNKW KLFLGLSSFG LLFVVFYFTH LEVSPITGRS KLLLLGKEQF RLLSELEYEA WMEEFKNDML TEKDARYLAV KEVLCHLIEC NKDVPGISQI NWVIHVVDSP IINAFVLPNG QMFVFTGFLN SVTDIHQLSF LLGHEIAHAV LGHAAEKAGM VHLLDFLGMI FLTMIWAICP RDSLALLCQW IQSKLQEYMF NRPYSRKLEA EADKIGLLLA AKACADIRAS SVFWQQMEFV DSLHGQPKMP EWLSTHPSHG NRVEYLDRLI PQALKIREMC NCPPLSNPDP RLLFKLSTKH FLEESEKEDL NITKKQKMDT LPIQKQEQIP LTYIVEKRTG S. It is sometimes possible for the material contained within the vial of "Metalloendopeptidase OMA1, mitochondrial (OMA1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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