PGRP-S/PGLYRP1 Recombinant Protein | PGLYRP1 recombinant protein

Recombinant Human PGRP-S/PGLYRP1 Protein (His Tag), HPLC-verified

Cat. Num. AAA259319

• Gene Names: PGLYRP1; PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
• Reactivity: Human
• Purity: >= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
• Synonyms: PGRP-S/PGLYRP1; N/A; Recombinant Human PGRP-S/PGLYRP1 Protein (His Tag), HPLC-verified; Human PGRP-S/PGLYRP1 Protein (His Tag); peptidoglycan recognition protein 1; PGLYRP Protein, Human; PGRP Protein, Human; PGRP-S Protein, Human; PGRPS Protein, Human; SBBI68 Protein, Human; TAG7 Protein, Human; TNFSF3L Protein, Human; UNQ639/PRO1269 Protein, Human; PGLYRP1 recombinant protein

• Host: HEK293 Cells
• Reactivity: Human
• Purity/Purification: >= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence: Met1-Pro196

• Tag: C-His
• Predicted N Terminal: Gln 22
• Endotoxin: < 1.0 EU perug protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the Human PGLYRP1 (O75594)(Met1-Pro196) was expressed with a polyhistidine tag at the C-terminus.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Application Data

Application Data

Related Product Information for PGLYRP1 recombinant protein

Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1/PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1/PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. It has bactericidal activity towards Gram-positive bacteria. PGLYRP1/PGLYRP may kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. It binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are innate immunity proteins that are conserved from insects to mammals, recognize bacterial peptidoglycan, and function in antibacterial immunity and inflammation. Mammals have four PGRPs: PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4. They are secreted proteins expressed in polymorphonuclear leukocytes (PGLYRP1), liver (PGLYRP2), or on body surfaces, mucous membranes, and in secretions (saliva, sweat)(PGLYRP3 and PGLYRP4). All PGRPs recognize bacterial peptidoglycan. The PGRPs likely play a role both in antibacterial defenses and several inflammatory diseases. They modulate local inflammatory responses in tissues (such as arthritic joints) and there is evidence for association of PGRPs with inflammatory diseases, such as psoriasis.

References

Kan. D.. e. al.,(1998). . peptidoglyca. recognitio. protei. i. innat. immunit. conserve. fro. insect. t. humans. Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082.Li. C.. e. al.. (2001). Peptidoglyca. recognitio. proteins. . nove. famil. o. fou. huma. innat. immunit. patter. recognitio. molecules.J. Biol. Chem. 276:34686-34694.Clar. H.F.. e. al.,(2003). Th. secrete. protei. discover. initiativ. (SPDI). . large-scal. effor. t. identif. nove. huma. secrete. an. transmembran. proteins. . bioinformatic. assessment.Genom. Res. 13:2265-2270.

NCBI and Uniprot Product Information

• NCBI GI #: 4827036
• NCBI GeneID: 8993
• NCBI Accession #: NP_005082.1
• NCBI GenBank Nucleotide #: NM_005091.2
• UniProt Accession #: O75594; Q4VB36
• Molecular Weight: 21,731 Da
• NCBI Official Full Name: peptidoglycan recognition protein 1
• NCBI Official Synonym Full Names: peptidoglycan recognition protein 1
• NCBI Official Symbol: PGLYRP1
• NCBI Official Synonym Symbols: PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
• NCBI Protein Information: peptidoglycan recognition protein 1; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
• UniProt Protein Name: Peptidoglycan recognition protein 1
• UniProt Gene Name: PGLYRP1
• UniProt Synonym Gene Names: PGLYRP; PGRP; TNFSF3L; PGRP-S
• UniProt Entry Name: PGRP1_HUMAN