Bioactivity
(Peptidoglycan is coated at 10 ug/ml (100 ul/well) can bind Human PGLYRP1. The ED50 range )
PGLYRP1/PGRP-S active protein
Recombinant human PGLYRP1/PGRP-S protein
Gene Names
PGLYRP1; PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
Applications
SDS-Page
Purity
>95% by SDS-PAGE
Synonyms
PGLYRP1/PGRP-S; N/A; Recombinant human PGLYRP1/PGRP-S protein; PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L; Peptidoglycan recognition protein 1; peptidoglycan recognition protein short; PGLYRP1/PGRP-S active protein
Host
HEK293
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence Positions
22-196aa
Sequence
Applicable Applications for PGLYRP1/PGRP-S active protein
Bioactivity, SDS-PAGE
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Species
Human
Tag
His-Tag
Predicted N-term
Asp
Bioactivity
Measured by its binding ability in a functional ELISA with Peptidoglycan. The ED50 range <= 30ng/ml.
Preparation and Storage
Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles
Bioactivity
(Peptidoglycan is coated at 10 ug/ml (100 ul/well) can bind Human PGLYRP1. The ED50 range )
Bioactivity
(Peptidoglycan is coated at 10 ug/ml (100 ul/well) can bind Human PGLYRP1. The ED50 range )
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
Related Product Information for PGLYRP1/PGRP-S active protein
PGLYRP1, also known as peptidoglycan recognition protein 1, is an innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. It acts as a pattern receptor that binds to murein peptidoglycans of gram-positive bacteria and provides bactericidal activity. PGLYRP1 forms an equimolar complex with HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. This protein also interacts with S100A4 and function as a chmoattractant which induces lymphocyte movement. Recombinant human PGLYRP1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
References
Lang MF, et al, (2008) Neurosci Lett. 430:138-141. Sharma P., et al, (2012) Int J Biochem Mol Biol. 3:86-94. Sun Q., et al, (2014) World J Microbiol Biotechnol. 30:263-270.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,731 Da
NCBI Official Full Name
peptidoglycan recognition protein 1
NCBI Official Synonym Full Names
peptidoglycan recognition protein 1
NCBI Official Symbol
PGLYRP1
NCBI Official Synonym Symbols
PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
NCBI Protein Information
peptidoglycan recognition protein 1; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
UniProt Protein Name
Peptidoglycan recognition protein 1
UniProt Gene Name
PGLYRP1
UniProt Synonym Gene Names
PGLYRP; PGRP; TNFSF3L; PGRP-S
UniProt Entry Name
PGRP1_HUMAN
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Product Notes
The PGLYRP1/PGRP-S pglyrp1 (Catalog #AAA48403) is an Active Protein produced from HEK293 and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-196aa. AAA Biotech's PGLYRP1/PGRP-S can be used in a range of immunoassay formats including, but not limited to, Bioactivity, SDS-PAGE. Researchers should empirically determine the suitability of the PGLYRP1/PGRP-S pglyrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below:Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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