FCM/FACS (Flow Cytometry)
(ABCD2 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit anti-Human ABCD2 Polyclonal Antibody | anti-ABCD2 antibody
ABCD2 Antibody (C-term)
Gene Names
ABCD2; ALDR; ABC39; ALDL1; ALDRP; hALDR
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ABCD2, Antibody; ABCD2 Antibody (C-term); ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR; ABCD2; ALD1; ALDL1; ALDR; ALDRP; anti-ABCD2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
553-582
Sequence Length
740
Applicable Applications for anti-ABCD2 antibody
FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(ABCD2 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(ABCD2 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(ABCD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABCD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(ABCD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABCD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(ABCD2 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCD2 antibody detected the ABCD2 protein (arrow).)
WB (Western Blot)
(ABCD2 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCD2 antibody detected the ABCD2 protein (arrow).)
Related Product Information for anti-ABCD2 antibody
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. The
function of this peroxisomal membrane protein is unknown; however
this protein is speculated to function as a dimerization partner of
ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
gene have been observed in patients with adrenoleukodystrophy, a
severe demyelinating disease. This gene has been identified as a
candidate for a modifier gene, accounting for the extreme variation
among adrenoleukodystrophy phenotypes. This gene is also a
candidate for a complement group of Zellweger syndrome, a
genetically heterogeneous disorder of peroxisomal biogenesis.
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. The
function of this peroxisomal membrane protein is unknown; however
this protein is speculated to function as a dimerization partner of
ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
gene have been observed in patients with adrenoleukodystrophy, a
severe demyelinating disease. This gene has been identified as a
candidate for a modifier gene, accounting for the extreme variation
among adrenoleukodystrophy phenotypes. This gene is also a
candidate for a complement group of Zellweger syndrome, a
genetically heterogeneous disorder of peroxisomal biogenesis.
Product Categories/Family for anti-ABCD2 antibody
References
Matsukawa, T., et al. Neurogenetics (2010) In press :
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Petroni, A., et al. J. Inherit. Metab. Dis. 30 (5), 828 (2007) :
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Petroni, A., et al. J. Inherit. Metab. Dis. 30 (5), 828 (2007) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
83233
NCBI Official Full Name
ATP-binding cassette sub-family D member 2
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family D (ALD), member 2
NCBI Official Symbol
ABCD2
NCBI Official Synonym Symbols
ALDR; ABC39; ALDL1; ALDRP; hALDR
NCBI Protein Information
ATP-binding cassette sub-family D member 2
UniProt Protein Name
ATP-binding cassette sub-family D member 2
UniProt Gene Name
ABCD2
UniProt Synonym Gene Names
ALD1; ALDL1; ALDR; ALDRP; hALDR
UniProt Entry Name
ABCD2_HUMAN
Similar Products
Product Notes
The ABCD2 abcd2 (Catalog #AAA287161) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 553-582. The ABCD2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ABCD2 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ABCD2 abcd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ABCD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.