WB (Western Blot)
(Figure 1. Western blot analysis of ADAM15 using anti-ADAM15 antibody.)
Rabbit anti-Human ADAM15 Polyclonal Antibody | anti-ADAM15 antibody
Anti-ADAM15 Antibody
Gene Names
ADAM15; MDC15
Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional Assay, Western Blot
Purity
Immunogen affinity purified.
Synonyms
ADAM15, Antibody; Anti-ADAM15 Antibody; Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin; ADAM15; MDC15; ADAM metallopeptidase domain 15; anti-ADAM15 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
824
Applicable Applications for anti-ADAM15 antibody
ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot)
Immunogen
E Coli-derived human ADAM15 recombinant protein (Position: R41-R456).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Figure 1. Western blot analysis of ADAM15 using anti-ADAM15 antibody.)
WB (Western Blot)
(Figure 1. Western blot analysis of ADAM15 using anti-ADAM15 antibody.)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
Related Product Information for anti-ADAM15 antibody
Description: Rabbit IgG polyclonal antibody for ADAM15 detection. Tested with WB, FCM, Direct ELISA in Human.
Background: Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene. This gene is mapped to 1q21.3. The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Background: Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene. This gene is mapped to 1q21.3. The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
References
1. Herren, B., Raines, E. W., Ross, R. Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. FASEB J. 11: 173-180, 1997.
2. Horiuchi, K., Weskamp, G., Lum, L., Hammes, H.-P., Cai, H., Brodie, T. A., Ludwig, T., Chiusaroli, R., Baron, R., Preissner, K. T., Manova, K., Blobel, C. P. Potential role for ADAM15 in pathological neovascularization in mice. Molec. Cell. Biol. 23: 5614-5624, 2003.
3. Karkkainen, I., Karhu, R., Huovila, A.-P. J. Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization. Cytogenet. Cell Genet. 88: 206-207, 2000.
2. Horiuchi, K., Weskamp, G., Lum, L., Hammes, H.-P., Cai, H., Brodie, T. A., Ludwig, T., Chiusaroli, R., Baron, R., Preissner, K. T., Manova, K., Blobel, C. P. Potential role for ADAM15 in pathological neovascularization in mice. Molec. Cell. Biol. 23: 5614-5624, 2003.
3. Karkkainen, I., Karhu, R., Huovila, A.-P. J. Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization. Cytogenet. Cell Genet. 88: 206-207, 2000.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 15
NCBI Official Symbol
ADAM15
NCBI Official Synonym Symbols
MDC15
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 15
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 15
UniProt Gene Name
ADAM15
UniProt Synonym Gene Names
MDC15; ADAM 15; MDC-15
UniProt Entry Name
ADA15_HUMAN
Similar Products
Product Notes
The ADAM15 adam15 (Catalog #AAA125454) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ADAM15 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADAM15 can be used in a range of immunoassay formats including, but not limited to, ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot). Researchers should empirically determine the suitability of the ADAM15 adam15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADAM15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.