IHC (Immunohiostchemistry)
(ADRA2C Antibody (C-term) (AAA286483)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ADRA2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit ADRA2C Polyclonal Antibody | anti-ADRA2C antibody
ADRA2C Antibody (C-term)
Gene Names
ADRA2C; ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ADRA2C, Antibody; ADRA2C Antibody (C-term); Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR; ADRA2C; ADRA2L2; ADRA2RL2; anti-ADRA2C antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the C-terminal region of human ADRA2C.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
354-382
Sequence Length
462
Applicable Applications for anti-ADRA2C antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(ADRA2C Antibody (C-term) (AAA286483)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ADRA2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(ADRA2C Antibody (C-term) (AAA286483)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ADRA2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(ADRA2C Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ADRA2C antibody detected the ADRA2C protein (arrow).)
WB (Western Blot)
(ADRA2C Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ADRA2C antibody detected the ADRA2C protein (arrow).)
Related Product Information for anti-ADRA2C antibody
Alpha-2-adrenergic receptors are members of the G
protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
have a critical role in regulating neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the central
nervous system. The mouse studies revealed that both the alpha2A
and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and
from central noradrenergic neurons. The alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the
alpha2C subtype modulated neurotransmission at lower levels of
nerve activity. This gene encodes the alpha2C subtype, which
contains no introns in either its coding or untranslated sequences.
protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
have a critical role in regulating neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the central
nervous system. The mouse studies revealed that both the alpha2A
and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and
from central noradrenergic neurons. The alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the
alpha2C subtype modulated neurotransmission at lower levels of
nerve activity. This gene encodes the alpha2C subtype, which
contains no introns in either its coding or untranslated sequences.
Product Categories/Family for anti-ADRA2C antibody
References
Chen, Q.J., et al. Clin. Biochem. 43(15):1201-1204(2010)
Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Gao, Y., et al. Ophthalmology (2010) In press :
Montgomery, M.D., et al. Br. J. Pharmacol. 159(4):820-830(2010)
Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Gao, Y., et al. Ophthalmology (2010) In press :
Montgomery, M.D., et al. Br. J. Pharmacol. 159(4):820-830(2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49522
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Symbol
ADRA2C
NCBI Official Synonym Symbols
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
NCBI Protein Information
alpha-2C adrenergic receptor
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Gene Name
ADRA2C
UniProt Synonym Gene Names
ADRA2L2; ADRA2RL2; Alpha-2C adrenoceptor; Alpha-2CAR
UniProt Entry Name
ADA2C_HUMAN
Similar Products
Product Notes
The ADRA2C adra2c (Catalog #AAA286483) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 354-382. The ADRA2C Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ADRA2C can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ADRA2C adra2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRA2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.