IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded mouse liver using at dilution of 1:50.)
Rabbit anti-Human Advanced glycosylation end product-specific receptor Polyclonal Antibody | anti-AGER antibody
Advanced glycosylation end product-specific receptor Polyclonal Antibody
Gene Names
AGER; RAGE
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Synonyms
Advanced glycosylation end product-specific receptor, Antibody; Advanced glycosylation end product-specific receptor Polyclonal Antibody; Receptor for advanced glycosylation end products; AGER; RAGE; anti-AGER antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total Advanced glycosylation end product-specific receptor polyclonal antibody.
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
404
Applicable Applications for anti-AGER antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
Recombinant Human Advanced glycosylation end product-specific receptor protein
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded mouse liver using at dilution of 1:50.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded mouse liver using at dilution of 1:50.)
WB (Western Blot)
(All lanes: Advanced glycosylation end product-specific receptor antibody at 2ug/mlLane 1 : EC109 whole cell lysateLane 2 : 293T whole cell lysate)
WB (Western Blot)
(All lanes: Advanced glycosylation end product-specific receptor antibody at 2ug/mlLane 1 : EC109 whole cell lysateLane 2 : 293T whole cell lysate)
Related Product Information for anti-AGER antibody
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Product Categories/Family for anti-AGER antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
41,098 Da
NCBI Official Full Name
advanced glycosylation end product-specific receptor isoform 1
NCBI Official Synonym Full Names
advanced glycosylation end product-specific receptor
NCBI Official Symbol
AGER
NCBI Official Synonym Symbols
RAGE
NCBI Protein Information
advanced glycosylation end product-specific receptor
UniProt Protein Name
Advanced glycosylation end product-specific receptor
UniProt Gene Name
AGER
UniProt Synonym Gene Names
RAGE
UniProt Entry Name
RAGE_HUMAN
Similar Products
Product Notes
The AGER ager (Catalog #AAA308504) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Advanced glycosylation end product-specific receptor Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Advanced glycosylation end product-specific receptor can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the AGER ager for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Advanced glycosylation end product-specific receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.