Rabbit AHI1 Polyclonal Antibody | anti-AHI1 antibody

AHI1 Antibody

Cat. Num. AAA328765

• Gene Names: AHI1; ORF1; AHI-1; JBTS3; dJ71N10.1
• Reactivity: Human, Mouse; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: AHI1, Antibody; AHI1 Antibody; Abelson helper integration site 1; Abelson helper integration site 1 protein homolog; Abelson helper integration site; AHI 1; AHI-1; Ahi1; AHI1_HUMAN; Contatins SH3 and WD40 domains; dJ71N10.1; DKFZp686J1653; FLJ14023; FLJ20069; JBTS3; Jouberin; ORF1; OTTHUMP00000017263; OTTHUMP00000017265; OTTHUMP00000234456; OTTHUMP00000234654; OTTHUMP00000234656; anti-AHI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: AHI1 Antibody detects endogenous levels of AHI1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1196

• Applicable Applications for anti-AHI1 antibody: WB (Western Blot)
• Immunogen: A synthesized peptide derived from human AHI1.
• Tissue Specificity: Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Cytoskeleton
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

WB (Western Blot)

(Western blot analysis of extracts from HEK-293 cells, using AHI1 Antibody. The lane on the left was treated with blocking peptide.)

WB (Western Blot)

(Western blot analysis of extracts from MCF7, using AHI1 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-AHI1 antibody

Description: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382).

Subunit Structure: Self-associates (PubMed:23532844). Part of the tectonic-like complex (also named B9 complex). Interacts with MKS1. Interacts with NPHP1; probably as heterodimers and/or AHI12:NPHP12 heterotetramers. Interacts (via SH3 domain) with the dynamin GTPase DNM2. Interacts with HAP1; probably as AHI12:HAP12 heterotetramers. Interacts with RAB8A (By similarity). Interacts with CEND1 (By similarity). Interacts with CTNNB1/beta-catenin (PubMed:21623382).

NCBI and Uniprot Product Information

• NCBI GI #: 31542701
• NCBI GeneID: 54806
• NCBI Accession #: NP_060121.3
• NCBI GenBank Nucleotide #: NP_060121.3
• UniProt Accession #: Q8N157
• Molecular Weight: Observed: 137 kDa; Predicted: 138 kDa
• NCBI Official Full Name: jouberin isoform a
• NCBI Official Synonym Full Names: Abelson helper integration site 1
• NCBI Official Symbol: AHI1
• NCBI Official Synonym Symbols: ORF1; AHI-1; JBTS3; dJ71N10.1
• NCBI Protein Information: jouberin
• UniProt Protein Name: Jouberin
• UniProt Gene Name: AHI1
• UniProt Synonym Gene Names: AHI-1
• UniProt Entry Name: AHI1_HUMAN