ICC (Immunocytochemistry)
(Immunocytochemistry of APC8 in K562 cells with APC8 antibody at 5 ug/mL.)
Rabbit APC8 Polyclonal Antibody | anti-APC8 antibody
APC8 Antibody
Gene Names
CDC23; APC8; CUT23; ANAPC8
Reactivity
Human, Mouse, Rat
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
APC8, Antibody; APC8 Antibody; Anaphase promoting complex 8, ANAPC8, CDC23; anti-APC8 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
597
Applicable Applications for anti-APC8 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 17 amino acid peptide near the center of human APC8.
Target Name
APC8
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of APC8 in K562 cells with APC8 antibody at 5 ug/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of APC8 in K562 cells with APC8 antibody at 5 ug/mL.)
WB (Western Blot)
(Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-APC8 antibody
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.
Product Categories/Family for anti-APC8 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,882 Da
NCBI Official Full Name
cell division cycle protein 23 homolog
NCBI Official Synonym Full Names
cell division cycle 23
NCBI Official Symbol
CDC23
NCBI Official Synonym Symbols
APC8; CUT23; ANAPC8
NCBI Protein Information
cell division cycle protein 23 homolog
UniProt Protein Name
Cell division cycle protein 23 homolog
UniProt Gene Name
CDC23
UniProt Synonym Gene Names
ANAPC8; APC8
UniProt Entry Name
CDC23_HUMAN
Similar Products
Product Notes
The APC8 cdc23 (Catalog #AAA307180) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC8 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's APC8 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the APC8 cdc23 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APC8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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