IHC (Immunohiostchemistry)
(APOBEC3B Antibody-Human Breast Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human APOBEC3B Polyclonal Antibody | anti-APOBEC3B antibody
APOBEC3B Rabbit anti-Human Polyclonal Antibody
Gene Names
APOBEC3B; A3B; ARP4; ARCD3; PHRBNL; APOBEC1L; bK150C2.2; DJ742C19.2
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
APOBEC3B, Antibody; APOBEC3B Rabbit anti-Human Polyclonal Antibody; PathPlus APOBEC3B Antibody; APOBEC3B; APOBEC1L; ARCD3; BK150C2.2; Cytidine deaminase; DJ742C19.2; Phorbolin 2; Phorbolin-1-related protein; PHRBNL; ARP4; Phorbolin 3; Phorbolin-2/3; anti-APOBEC3B antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
0.81mg/ml (varies by lot)
Applicable Applications for anti-APOBEC3B antibody
IHC (Immunohistochemistry)
Target
Human APOBEC3B
Immunogen
LP-11154, synthetic peptide
Conjugation
Unconjugated
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohiostchemistry)
(APOBEC3B Antibody-Human Breast Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(APOBEC3B Antibody-Human Breast Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(APOBEC3B Antibody-Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(APOBEC3B Antibody-Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-APOBEC3B antibody
APOBEC3B antibody is an unconjugated rabbit polyclonal antibody to APOBEC3B from human. Validated for IHC.
APOBEC3B is a repair gene and cytidine deaminase involved in somatic hypermutation. The deregulation or dysfunction of APOBEC3B and other members of the APOBEC family has been implicated as a direct source of mutagenesis in breast and other cancers. APOBEC3B is upregulated in a number of breast cancers, and this upregulation correlates with a mutation spectrum (kataegis) in these tumors consistent with APOBEC function and may be a simultaneous or upstream consequence of ERBB2 amplification. APOBEC mutation signatures have also been identified in lung cancer, as well as evidence of APOBEC3B upregulation in lung cancer and a correlation between increased expression and worse prognosis in non-small-cell lung carcinoma (NSCLC), making it an important potential biomarker for the disease. In immunohistochemistry, APOBEC3B has low levels of nuclear positivity in tissues throughout the body, with highest expression in peripheral blood leukocytes and in the spleen, heart, thymus, prostate, ovary, and testes.
APOBEC3B is a repair gene and cytidine deaminase involved in somatic hypermutation. The deregulation or dysfunction of APOBEC3B and other members of the APOBEC family has been implicated as a direct source of mutagenesis in breast and other cancers. APOBEC3B is upregulated in a number of breast cancers, and this upregulation correlates with a mutation spectrum (kataegis) in these tumors consistent with APOBEC function and may be a simultaneous or upstream consequence of ERBB2 amplification. APOBEC mutation signatures have also been identified in lung cancer, as well as evidence of APOBEC3B upregulation in lung cancer and a correlation between increased expression and worse prognosis in non-small-cell lung carcinoma (NSCLC), making it an important potential biomarker for the disease. In immunohistochemistry, APOBEC3B has low levels of nuclear positivity in tissues throughout the body, with highest expression in peripheral blood leukocytes and in the spleen, heart, thymus, prostate, ovary, and testes.
References
Genome Biol. 2016; 17: 185, PMID: 27634334; eLife. 2013; 2: e00534, PMID: 23599896; Oncogene. 2018 Jul;37(29):3924-3936, PMID: 29695832; Elife. 2013 Apr 16;2:e00534. doi: 10.7554/eLife.00534, PMID: 23599896; Br J Cancer. 2017 Jun 27; 117(1): 113 -123, PMID: 28535155;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,081 Da
NCBI Official Full Name
DNA dC->dU-editing enzyme APOBEC-3B isoform a
NCBI Official Synonym Full Names
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3B
NCBI Official Symbol
APOBEC3B
NCBI Official Synonym Symbols
A3B; ARP4; ARCD3; PHRBNL; APOBEC1L; bK150C2.2; DJ742C19.2
NCBI Protein Information
DNA dC->dU-editing enzyme APOBEC-3B
UniProt Protein Name
DNA dC->dU-editing enzyme APOBEC-3B
UniProt Gene Name
APOBEC3B
UniProt Synonym Gene Names
A3B
UniProt Entry Name
ABC3B_HUMAN
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Product Notes
The APOBEC3B apobec3b (Catalog #AAA163029) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APOBEC3B Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APOBEC3B can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the APOBEC3B apobec3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APOBEC3B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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