IHC (Immunohiostchemistry)
(ARHGEF3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ARHGEF3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit ARHGEF3 Polyclonal Antibody | anti-ARHGEF3 antibody
ARHGEF3 Antibody (Center)
Gene Names
ARHGEF3; GEF3; STA3; XPLN
Reactivity
Human (Predicted Reactivity: Chicken, Monkey, Mouse)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ARHGEF3, Antibody; ARHGEF3 Antibody (Center); Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN; ARHGEF3; anti-ARHGEF3 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Chicken, Monkey, Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
211-240
Sequence Length
324
Applicable Applications for anti-ARHGEF3 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(ARHGEF3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ARHGEF3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(ARHGEF3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ARHGEF3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(ARHGEF3 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ARHGEF3 antibody detected the ARHGEF3 protein (arrow).)
WB (Western Blot)
(ARHGEF3 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ARHGEF3 antibody detected the ARHGEF3 protein (arrow).)
Related Product Information for anti-ARHGEF3 antibody
Rho-like GTPases are involved in a variety of cellular
processes, and they are activated by binding GTP and inactivated by
conversion of GTP to GDP by their intrinsic GTPase activity.
Guanine nucleotide exchange factors (GEFs) accelerate the GTPase
activity of Rho GTPases by catalyzing their release of bound GDP.
This gene encodes a guanine nucleotide exchange factor, which
specifically activates two members of the Rho GTPase family: RHOA
and RHOB, both of which have a role in bone cell biology. It has
been identified that genetic variation in this gene plays a role in
the determination of bone mineral density (BMD), indicating the
implication of this gene in postmenopausal osteoporosis.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.
processes, and they are activated by binding GTP and inactivated by
conversion of GTP to GDP by their intrinsic GTPase activity.
Guanine nucleotide exchange factors (GEFs) accelerate the GTPase
activity of Rho GTPases by catalyzing their release of bound GDP.
This gene encodes a guanine nucleotide exchange factor, which
specifically activates two members of the Rho GTPase family: RHOA
and RHOB, both of which have a role in bone cell biology. It has
been identified that genetic variation in this gene plays a role in
the determination of bone mineral density (BMD), indicating the
implication of this gene in postmenopausal osteoporosis.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.
Product Categories/Family for anti-ARHGEF3 antibody
References
Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)
Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59783
NCBI Official Full Name
rho guanine nucleotide exchange factor 3 isoform 1
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 3
NCBI Official Symbol
ARHGEF3
NCBI Official Synonym Symbols
GEF3; STA3; XPLN
NCBI Protein Information
rho guanine nucleotide exchange factor 3
UniProt Protein Name
Rho guanine nucleotide exchange factor 3
UniProt Gene Name
ARHGEF3
UniProt Synonym Gene Names
XPLN
UniProt Entry Name
ARHG3_HUMAN
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Product Notes
The ARHGEF3 arhgef3 (Catalog #AAA284817) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 211-240. The ARHGEF3 Antibody (Center) reacts with Human (Predicted Reactivity: Chicken, Monkey, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's ARHGEF3 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ARHGEF3 arhgef3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARHGEF3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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