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IHC (Immunohistochemistry)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
Rabbit ASIC1 Polyclonal Antibody | anti-ASIC1 antibody
ASIC1 Polyclonal Antibody
Gene Names
ASIC1; ASIC; ACCN2; BNaC2
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Synonyms
ASIC1, Antibody; ASIC1 Polyclonal Antibody; Acid-sensing ion channel 1 (ASIC1)(Amiloride-sensitive cation channel 2; neuronal)(Brain sodium channel 2)(BNaC2); anti-ASIC1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Applicable Applications for anti-ASIC1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
IHC (Immunohistochemistry)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
WB (Western Blot)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
WB (Western Blot)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
IHC (Immunohiostchemistry)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
IHC (Immunohiostchemistry)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
WB (Western Blot)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
WB (Western Blot)
(Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000)
Related Product Information for anti-ASIC1 antibody
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca (2+) entry into neurons upon acidosis. This Ca (2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca (2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
62,700 Da
NCBI Official Full Name
acid-sensing ion channel 1 isoform c
NCBI Official Synonym Full Names
acid sensing ion channel subunit 1
NCBI Official Symbol
ASIC1
NCBI Official Synonym Symbols
ASIC; ACCN2; BNaC2
NCBI Protein Information
acid-sensing ion channel 1
UniProt Protein Name
Acid-sensing ion channel 1
UniProt Gene Name
ASIC1
UniProt Synonym Gene Names
ACCN2; BNAC2; ASIC1; BNaC2
UniProt Entry Name
ASIC1_HUMAN
Similar Products
Product Notes
The ASIC1 asic1 (Catalog #AAA296526) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASIC1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ASIC1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the ASIC1 asic1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASIC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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