Rabbit ATF6 Polyclonal Antibody | anti-ATF6 antibody

ATF6 Antibody

Cat. Num. AAA29696

• Gene Names: ATF6; ATF6A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: ATF6, Antibody; ATF6 Antibody; ATF6; ATF6A; Activatingtranscriptionfactor6alpha; anti-ATF6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total ATF6 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)

• Applicable Applications for anti-ATF6 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human ATF6.
• Target Name: ATF6
• Preparation and Storage: Store at -20°C.

IF (Immunofluorescence)

(Immunofluorescence analysis of A549 cell using ATF6 antibody. Blue: DAPI for nuclear staining)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded rat spleen using ATF6 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded rat lung using ATF6 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human lung cancer using ATF6 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human lung using ATF6 antibody at dilution of 1:200 (200x lens).)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using ATF6 antibody.)

Related Product Information for anti-ATF6 antibody

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Product Categories/Family for anti-ATF6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 56786157
• NCBI GeneID: 22926
• NCBI Accession #: NP_031374.2
• NCBI GenBank Nucleotide #: NM_007348.3
• UniProt Accession #: P18850; O15139; Q5VW62; Q6IPB5; Q9UEC9
• Molecular Weight: SDS-PAGE MW 75KD
• NCBI Official Full Name: cyclic AMP-dependent transcription factor ATF-6 alpha
• NCBI Official Synonym Full Names: activating transcription factor 6
• NCBI Official Symbol: ATF6
• NCBI Official Synonym Symbols: ATF6A
• NCBI Protein Information: cyclic AMP-dependent transcription factor ATF-6 alpha
• UniProt Protein Name: Cyclic AMP-dependent transcription factor ATF-6 alpha
• UniProt Gene Name: ATF6
• UniProt Synonym Gene Names: cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha
• UniProt Entry Name: ATF6A_HUMAN