WB (Western Blot)
(ATL1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATL1 antibody detected the ATL1 protein (arrow).)
Rabbit ATL1 Polyclonal Antibody | anti-ATL1 antibody
ATL1 Antibody (C-term)
Gene Names
ATL1; FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat)
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ATL1, Antibody; ATL1 Antibody (C-term); Atlastin-1; 365-; Brain-specific GTP-binding protein; GTP-binding protein 3; GBP-3; hGBP3; Guanine nucleotide-binding protein 3; Spastic paraplegia 3 protein A; ATL1; GBP3; SPG3A; anti-ATL1 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB36288
Specificity
This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-504 amino acids from the C-terminal region of human ATL1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
477-504
Applicable Applications for anti-ATL1 antibody
ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
GTPase tethering membranes throughformation of trans- homooligomers andmediating homotypic fusion of endoplasmicreticulum membranes. Functions inendoplasmic reticulum tubular networkbiogenesis (PubMed: ). May alsoregulate Golgi biogenesis. May regulateaxonal development.
Cellular Location
Endoplasmic reticulum membrane; Multi-passmembrane protein. Golgi apparatusmembrane; Multi-pass membrane protein.Cell projection, axon{ECO:0000250|UniProtKB:Q6PST4}. Note=Localizes to endoplasmic reticulumtubular network (PubMed:27619977)
Tissue Location
Expressed predominantly in the adult andfetal central nervous system. Measurableexpression in all tissues examined, althoughexpression in adult brain is at least 50-foldhigher than in other tissues. Detectedpredominantly in pyramidal neurons in thecerebral cortex and the hippocampus of thebrain Expressed in upper and lower motorneurons (at protein level)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(ATL1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATL1 antibody detected the ATL1 protein (arrow).)
WB (Western Blot)
(ATL1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATL1 antibody detected the ATL1 protein (arrow).)
Related Product Information for anti-ATL1 antibody
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Product Categories/Family for anti-ATL1 antibody
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Park, S.H., et al. J. Clin. Invest. 120(4):1097-1110(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
de Leva, M.F., et al. J. Neurol. 257(3):328-331(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Park, S.H., et al. J. Clin. Invest. 120(4):1097-1110(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
de Leva, M.F., et al. J. Neurol. 257(3):328-331(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
atlastin-1 isoform b
NCBI Official Synonym Full Names
atlastin GTPase 1
NCBI Official Symbol
ATL1
NCBI Official Synonym Symbols
FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
NCBI Protein Information
atlastin-1
UniProt Protein Name
Atlastin-1
UniProt Gene Name
ATL1
UniProt Synonym Gene Names
GBP3; SPG3A; GBP-3; hGBP3
UniProt Entry Name
ATLA1_HUMAN
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Product Notes
The ATL1 atl1 (Catalog #AAA284554) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 477-504. The ATL1 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ATL1 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ATL1 atl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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