IHC (Immunohiostchemistry)
(Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/mL.)
Rabbit Aven Polyclonal Antibody | anti-AVEN antibody
Aven Antibody
Gene Names
AVEN; PDCD12
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
Aven, Antibody; Aven Antibody; Apoptosis caspase activation inhibitor; anti-AVEN antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
362
Applicable Applications for anti-AVEN antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 18 amino acid peptide from near the amino terminus of human Aven.
Target Name
Aven
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/mL.)
WB (Western Blot)
(Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/mL in (A) the presence and (B) the absence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/mL in (A) the presence and (B) the absence of blocking peptide.)
Related Product Information for anti-AVEN antibody
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Product Categories/Family for anti-AVEN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,506 Da
NCBI Official Full Name
cell death regulator Aven
NCBI Official Synonym Full Names
apoptosis, caspase activation inhibitor
NCBI Official Symbol
AVEN
NCBI Official Synonym Symbols
PDCD12
NCBI Protein Information
cell death regulator Aven
UniProt Protein Name
Cell death regulator Aven
UniProt Gene Name
AVEN
UniProt Entry Name
AVEN_HUMAN
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Product Notes
The AVEN aven (Catalog #AAA305699) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Aven Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Aven can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the AVEN aven for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Aven, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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