Rabbit anti-Human, Mouse Bik Polyclonal Antibody | anti-Bik antibody

Bik Antibody

Cat. Num. AAA302274

• Gene Names: BIK; BP4; NBK; BIP1
• Reactivity: Human, Mouse
• Applications: Immunocytochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Bik, Antibody; Bik Antibody; Bcl-2-interacting killer, apoptosis inducer NBK; anti-Bik antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 160

• Applicable Applications for anti-Bik antibody: ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the amino terminus of human BIK.
• Target Name: Bik
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of BIK in Jurkat cells with BIK antibody at 1 ug/mL.)

WB (Western Blot)

(Western blot analysis of BIK in Jurkat cell lysate with BIK antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-Bik antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.

Product Categories/Family for anti-Bik antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 47678311
• NCBI GeneID: 638
• UniProt Accession #: Q13323; Q16582; Q6FH93
• Molecular Weight: 18,016 Da
• NCBI Official Full Name: BIK
• NCBI Official Synonym Full Names: BCL2-interacting killer (apoptosis-inducing)
• NCBI Official Symbol: BIK
• NCBI Official Synonym Symbols: BP4; NBK; BIP1
• NCBI Protein Information: bcl-2-interacting killer
• UniProt Protein Name: Bcl-2-interacting killer
• UniProt Gene Name: BIK
• UniProt Synonym Gene Names: NBK
• UniProt Entry Name: BIK_HUMAN