Rabbit anti-Human c-Abl/ABL1 Polyclonal Antibody | anti-ABL1 antibody

Anti-c-Abl/ABL1 Antibody, Rabbit Polyclonal

Cat. Num. AAA255349

• Gene Names: ABL1; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Immunohistochemistry, ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: c-Abl/ABL1, Antibody; Anti-c-Abl/ABL1 Antibody, Rabbit Polyclonal; c-Abl/ABL1 Antibody, Rabbit PAb, Antigen Affinity Purified; ABL proto-oncogene 1, non-receptor tyrosine kinase; Anti-ABL Antibody; Anti-bcr/abl Antibody; Anti-c-ABL Antibody; Anti-c-ABL1 Antibody; Anti-JTK7 Antibody; Anti-p150 Antibody; Anti-v-abl Antibody; anti-ABL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human c-Abl/ABL1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-ABL1 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant Human c-Abl/ABL1 Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human c-Abl/ABL1 (rh c-Abl/ABL1). c-Abl/ABL1 specific IgG was purified by Human c-Abl/ABL1 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IF (Immunofluorescence)

(Immunofluorescence staining of ABL1 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human ABL1 polyclonal antibody (1:1000) at 4 degree C overnight. Then cells were stained with the Alexa Fluor488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm and nucleus.)

IHC (Immunohistochemistry)

(Immunochemical staining of human ABL1 in human breast carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-ABL1 antibody

c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra-and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.

Product Categories/Family for anti-ABL1 antibody

Cancer Drug Targets; Jak-Stat Signaling Pathway

References

Qiu Z, et al. (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 107(3): 1136-41.
Huang Y, et al. (2008) The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood. 112(1): 111-9.
Sirvent A, et al. (2008) Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell. 100(11): 617-31.
Shaul Y, et al. (2005) Role of c-Abl in the DNA damage stress response. Cell Res. 15(1): 33-5.

NCBI and Uniprot Product Information

• NCBI GI #: 62362412
• NCBI GeneID: 25
• NCBI Accession #: NP_009297.2
• NCBI GenBank Nucleotide #: NM_007313.2
• UniProt Accession #: P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09; A3KFJ3
• Molecular Weight: 124,955 Da
• NCBI Official Full Name: tyrosine-protein kinase ABL1 isoform b
• NCBI Official Synonym Full Names: ABL proto-oncogene 1, non-receptor tyrosine kinase
• NCBI Official Symbol: ABL1
• NCBI Official Synonym Symbols: ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
• NCBI Protein Information: tyrosine-protein kinase ABL1
• UniProt Protein Name: Tyrosine-protein kinase ABL1
• UniProt Gene Name: ABL1
• UniProt Synonym Gene Names: ABL; JTK7
• UniProt Entry Name: ABL1_HUMAN