IHC (Immunohiostchemistry)
(C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human C10orf2 Polyclonal Antibody | anti-PEO1 antibody
C10orf2 Antibody (C-term)
Gene Names
C10orf2; PEO; PEO1; SCA8; ATXN8; IOSCA; PEOA3; SANDO; TWINL; MTDPS7; PRLTS5
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
C10orf2, Antibody; C10orf2 Antibody (C-term); Twinkle protein; mitochondrial; Progressive external ophthalmoplegia 1 protein; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; PEO1; C10orf2; anti-PEO1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This C10orf2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-684 amino acids from the C-terminal region of human C10orf2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.38 (varies by lot)
Sequence Positions
656-684
Sequence Length
531
Applicable Applications for anti-PEO1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(C10orf2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow).)
WB (Western Blot)
(C10orf2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow).)
Related Product Information for anti-PEO1 antibody
This gene encodes a hexameric DNA helicase which unwinds
short stretches of double-stranded DNA in the 5' to 3' direction
and, along with mitochondrial single-stranded DNA binding protein
and mtDNA polymerase gamma, is thought to play a key role in mtDNA
replication. The protein localizes to the mitochondrial matrix and
mitochondrial nucleoids. Mutations in this gene cause infantile
onset spinocerebellar ataxia (IOSCA) and progressive external
ophthalmoplegia (PEO) and are also associated with several
mitochondrial depletion syndromes. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.
short stretches of double-stranded DNA in the 5' to 3' direction
and, along with mitochondrial single-stranded DNA binding protein
and mtDNA polymerase gamma, is thought to play a key role in mtDNA
replication. The protein localizes to the mitochondrial matrix and
mitochondrial nucleoids. Mutations in this gene cause infantile
onset spinocerebellar ataxia (IOSCA) and progressive external
ophthalmoplegia (PEO) and are also associated with several
mitochondrial depletion syndromes. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.
Product Categories/Family for anti-PEO1 antibody
References
Longley, M.J., et al. J. Biol. Chem. 285(39):29690-29702(2010)
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Fratter, C., et al. Neurology 74(20):1619-1626(2010)
Kruger, J., et al. Mol Neurodegener 5, 8 (2010) :
Bohlega, S., et al. Neuromuscul. Disord. 19(12):845-848(2009)
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Fratter, C., et al. Neurology 74(20):1619-1626(2010)
Kruger, J., et al. Mol Neurodegener 5, 8 (2010) :
Bohlega, S., et al. Neuromuscul. Disord. 19(12):845-848(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
77154
NCBI Official Full Name
twinkle protein, mitochondrial isoform B
NCBI Official Synonym Full Names
chromosome 10 open reading frame 2
NCBI Official Symbol
C10orf2
NCBI Official Synonym Symbols
PEO; PEO1; SCA8; ATXN8; IOSCA; PEOA3; SANDO; TWINL; MTDPS7; PRLTS5
NCBI Protein Information
twinkle protein, mitochondrial
UniProt Protein Name
Twinkle protein, mitochondrial
UniProt Gene Name
PEO1
UniProt Synonym Gene Names
C10orf2
UniProt Entry Name
PEO1_HUMAN
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Product Notes
The PEO1 peo1 (Catalog #AAA284825) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 656-684. The C10orf2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's C10orf2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PEO1 peo1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C10orf2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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