WB (Western Blot)
(C2 Antibody (N-term) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the C2 antibody detected the C2 protein (arrow).)
Rabbit C2 Polyclonal Antibody | anti-C2 antibody
C2 Antibody (N-term)
Gene Names
C2; CO2; ARMD14
Reactivity
Human, hamster
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
C2, Antibody; C2 Antibody (N-term); Complement C2; C3/C5 convertase; Complement C2b fragment; Complement C2a fragment; C2; anti-C2 antibody
Host
Rabbit
Reactivity
Human, hamster
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.26 (varies by lot)
Sequence Positions
147-176
Sequence Length
620
Applicable Applications for anti-C2 antibody
ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Preparation and Storage
Maintain refrigerated at 2-8°C. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(C2 Antibody (N-term) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the C2 antibody detected the C2 protein (arrow).)
WB (Western Blot)
(C2 Antibody (N-term) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the C2 antibody detected the C2 protein (arrow).)
Related Product Information for anti-C2 antibody
Component C2 is a serum glycoprotein that functions as
part of the classical pathway of the complement system. Activated
C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then
combines with complement factor 4b to create the C3 or C5
convertase. Deficiency of C2 has been reported to associated with
certain autoimmune diseases and SNPs in this gene have been
associated with altered susceptibility to age-related macular
degeneration. This gene localizes within the class III region of
the MHC on the short arm of chromosome 6. Alternative splicing
results in multiple transcript variants encoding distinct isoforms.
Additional transcript variants have been described in publications
but their full-length sequence has not been determined.
part of the classical pathway of the complement system. Activated
C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then
combines with complement factor 4b to create the C3 or C5
convertase. Deficiency of C2 has been reported to associated with
certain autoimmune diseases and SNPs in this gene have been
associated with altered susceptibility to age-related macular
degeneration. This gene localizes within the class III region of
the MHC on the short arm of chromosome 6. Alternative splicing
results in multiple transcript variants encoding distinct isoforms.
Additional transcript variants have been described in publications
but their full-length sequence has not been determined.
Product Categories/Family for anti-C2 antibody
References
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Ishii, Y., et al. J. Immunol. 151(1):170-174(1993)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Ishii, Y., et al. J. Immunol. 151(1):170-174(1993)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated MW: 83268
NCBI Official Full Name
complement C2 isoform 1 preproprotein
NCBI Official Synonym Full Names
complement component 2
NCBI Official Symbol
C2
NCBI Official Synonym Symbols
CO2; ARMD14
NCBI Protein Information
complement C2
UniProt Protein Name
Complement C2
UniProt Gene Name
C2
UniProt Entry Name
CO2_HUMAN
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Product Notes
The C2 c2 (Catalog #AAA287217) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 147-176. The C2 Antibody (N-term) reacts with Human, hamster and may cross-react with other species as described in the data sheet. AAA Biotech's C2 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the C2 c2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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