WB (Western Blot)
(Western blot analysis of CACNA1C expression in Human Heart lysate in RIPA buffer, The lane on the left is treated with the antigen-specific peptide.)
Rabbit CACNA1C Polyclonal Antibody | anti-CACNA1C antibody
CACNA1C Antibody
Gene Names
CACNA1C; TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Peptide affinity purification
Synonyms
CACNA1C, Antibody; CACNA1C Antibody; anti-CACNA1C antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CACNA1C antibody detects endogenous levels of total CACNA1C.
Purity/Purification
Peptide affinity purification
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
2138
Applicable Applications for anti-CACNA1C antibody
ELISA, WB (Western Blot)
Immunogen
A synthesized peptide derived from human CACNA1C, corresponding to a region within C-terminal amino acids.
Preparation and Storage
Store at -20°C. Avoid freeze/thaw cycles.
WB (Western Blot)
(Western blot analysis of CACNA1C expression in Human Heart lysate in RIPA buffer, The lane on the left is treated with the antigen-specific peptide.)
WB (Western Blot)
(Western blot analysis of CACNA1C expression in Human Heart lysate in RIPA buffer, The lane on the left is treated with the antigen-specific peptide.)
Related Product Information for anti-CACNA1C antibody
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death (PubMed:29078335). The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.
Similarity: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Similarity: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
249 kDa
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 C
NCBI Official Symbol
CACNA1C
NCBI Official Synonym Symbols
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Gene Name
CACNA1C
UniProt Synonym Gene Names
CACH2; CACN2; CACNL1A1; CCHL1A1
Similar Products
Product Notes
The CACNA1C cacna1c (Catalog #AAA323359) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CACNA1C Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CACNA1C can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CACNA1C cacna1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CACNA1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.