Rabbit anti-Mouse, Human Calcineurin B/PPP3R1 Polyclonal Antibody | anti-PPP3R1 antibody

Anti-Calcineurin B/PPP3R1 Antibody, Rabbit Polyclonal

Cat. Num. AAA255068

• Gene Names: Ppp3r1; Cnb1; CaNB1; MCIP1
• Reactivity: Mouse, Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: Calcineurin B/PPP3R1, Antibody; Anti-Calcineurin B/PPP3R1 Antibody, Rabbit Polyclonal; Calcineurin B/PPP3R1 Antibody, Rabbit PAb, Antigen Affinity Purified; protein phosphatase 3, regulatory subunit B, alpha; Anti-CaNB1 Antibody; Anti-Cnb1 Antibody; Anti-MCIP1 Antibody; anti-PPP3R1 antibody

• Host: Rabbit
• Reactivity: Mouse, Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse Calcineurin B/PPP3R1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-PPP3R1 antibody: IHC (Immunohistochemistry)
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse Calcineurin B/PPP3R1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse Calcineurin B/PPP3R1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining PPP3R1 in human brain with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining PPP3R1 in mouse brain with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PPP3R1 antibody

PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. PPP3R1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase which takes a vital part in the T cell activation pathway. PPP3R1 is involved in protein dephosphorylation, NFAT protein import into nucleus (ortholog) and epithelial to mesenchymal transition (ortholog). It participates in calcineurin signaling pathway; mitogen activated protein kinase signaling pathway. PPP3R1 interacts with (+)-pilocarpine, 2, 4-dinitrotoluene and ammonium chloride. It contains four EF-hand domains and four functional calcium-binding sites. PPP3R1 plays an important role in the T cell activation pathway.

Product Categories/Family for anti-PPP3R1 antibody

Calcium-binding Proteins and Related Molecules; Actin Dynamics Signaling Pathway

References

Feng B, et al. (1999) Interactions of calcineurin A, calcineurin B, and Ca2+. Biochemistry 38 (38): 12481-9.Kawamura A, et al. (1995) Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. J Biol Chem. 270(26):15463-6.Wang MG, et al. (1997) Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21q22 and 2p16p15 respectively. Cytogenet Cell Genet. 72(2-3):236-41.

NCBI and Uniprot Product Information

• NCBI GI #: 84794597
• NCBI GeneID: 19058
• NCBI Accession #: NP_077779.2
• NCBI GenBank Nucleotide #: NM_024459.2
• UniProt Accession #: Q63810; Q3V067; Q5F225
• Molecular Weight: 18,208 Da
• NCBI Official Full Name: calcineurin subunit B type 1
• NCBI Official Synonym Full Names: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
• NCBI Official Symbol: Ppp3r1
• NCBI Official Synonym Symbols: Cnb1; CaNB1; MCIP1
• NCBI Protein Information: calcineurin subunit B type 1
• UniProt Protein Name: Calcineurin subunit B type 1
• UniProt Gene Name: Ppp3r1
• UniProt Synonym Gene Names: Cnb
• UniProt Entry Name: CANB1_MOUSE