IHC (Immunohistochemisry)
(Anti-Caspase-12 antibody, AAA45462, IHC(P)IHC(P): Human Lung Cancer Tissue)
Rabbit anti-Human Caspase-12 Polyclonal Antibody | anti-CASP12 antibody
Anti-Caspase-12 antibody
Gene Names
CASP12; CASP-12; CASP12P1
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
Caspase-12, Antibody; Anti-Caspase-12 antibody; Inactive caspase-12; caspase 12(gene/pseudogene); Apoptosis related cysteine protease antibody; CASP 12 antibody; CASP-12 antibody; casp12 antibody; CASP12P1 antibody; caspase 12(gene/pseudogene) antibody; caspase 12 pseudogene 1 antibody; Caspase 12 psuedogene 1 antibody; Caspase12 antibody; CASPC_HUMAN antibody; Inactive caspase-12 antibody; OTTHUMP00000207032 antibody; UNQ9415 antibody; anti-CASP12 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
341
Applicable Applications for anti-CASP12 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12 (71-84aa KIFREHLWNSKKQL).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohistochemisry)
(Anti-Caspase-12 antibody, AAA45462, IHC(P)IHC(P): Human Lung Cancer Tissue)
IHC (Immunohistochemisry)
(Anti-Caspase-12 antibody, AAA45462, IHC(P)IHC(P): Human Lung Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti-Caspase-12 antibody, AAA45462, IHC(P)IHC(P): Human Mammary Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti-Caspase-12 antibody, AAA45462, IHC(P)IHC(P): Human Mammary Cancer Tissue)
WB (Western Blot)
(Anti-Caspase-12 antibody, AAA45462, Western blottingAll lanes: Anti Caspase-12 (AAA45462) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: A549 Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
WB (Western Blot)
(Anti-Caspase-12 antibody, AAA45462, Western blottingAll lanes: Anti Caspase-12 (AAA45462) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: A549 Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Related Product Information for anti-CASP12 antibody
Description: Rabbit IgG polyclonal antibody for Inactive caspase-12(CASP12) detection. Tested with WB, IHC-P in Human.
Background: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
Background: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
29,399 Da
NCBI Official Full Name
Inactive caspase-12
NCBI Official Synonym Full Names
caspase 12 (gene/pseudogene)
NCBI Official Symbol
CASP12
NCBI Official Synonym Symbols
CASP-12; CASP12P1
NCBI Protein Information
inactive caspase-12; caspase 12 pseudogene 1
UniProt Protein Name
Inactive caspase-12
UniProt Gene Name
CASP12
UniProt Synonym Gene Names
CASP-12
UniProt Entry Name
CASPC_HUMAN
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Product Notes
The CASP12 casp12 (Catalog #AAA45462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Caspase-12 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Caspase-12 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CASP12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase-12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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