WB (Western Blot)
(Western blot analysis of Cav1.2 expression in mouse brain (A), rat brain (B) whole cell lysates.)
Rabbit Cav1.2 Polyclonal Antibody | anti-Cav1.2 antibody
Anti-Cav1.2 Antibody
Gene Names
CACNA1C; TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
Reactivity
Human, Mouse, Rat, Rabbit
Applications
Western Blot
Synonyms
Cav1.2, Antibody; Anti-Cav1.2 Antibody; CACH2; CACN2; CACNL1A1; CCHL1A1; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2; anti-Cav1.2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Rabbit
Clonality
Polyclonal
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
Applicable Applications for anti-Cav1.2 antibody
WB (Western Blot)
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: , PubMed: ). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed: , PubMed: , PubMed: , PubMed: , PubMed: ). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Cellular Location
Cell membrane; Multi-pass membrane protein Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15381}; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:P22002}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P22002}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22002}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q01815}. Note=Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane. {ECO:0000250|UniProtKB:P15381
Tissue Location
Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle Overall expression is reduced in atherosclerotic vascular smooth muscle.
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of Cav1.2 expression in mouse brain (A), rat brain (B) whole cell lysates.)
WB (Western Blot)
(Western blot analysis of Cav1.2 expression in mouse brain (A), rat brain (B) whole cell lysates.)
Related Product Information for anti-Cav1.2 antibody
Rabbit polyclonal antibody to Cav1.2
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cav1.2. The exact sequence is proprietary.
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cav1.2. The exact sequence is proprietary.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
252,507 Da
NCBI Official Full Name
voltage-gated calcium channel, partial
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 C
NCBI Official Symbol
CACNA1C
NCBI Official Synonym Symbols
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Gene Name
CACNA1C
UniProt Synonym Gene Names
CACH2; CACN2; CACNL1A1; CCHL1A1
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Product Notes
The Cav1.2 cacna1c (Catalog #AAA292440) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cav1.2 Antibody reacts with Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's Cav1.2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the Cav1.2 cacna1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cav1.2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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