IHC (Immunohiostchemistry)
(CB086 Antibody (C-term) (AAA286338) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CB086 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human CB086 Polyclonal Antibody | anti-WDPCP antibody
CB086 Antibody (C-term)
Gene Names
WDPCP; FRTZ; BBS15; FRITZ; CHDTHP; C2orf86
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CB086, Antibody; CB086 Antibody (C-term); WD repeat-containing and planar cell polarity effector protein fritz homolog; hFRTZ; Bardet-Biedl syndrome 15 protein; WD repeat-containing and planar cell polarity effector protein; WDPCP; BBS15; C2orf86; FRITZ; anti-WDPCP antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human CB086.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
676-705
Sequence Length
746
Applicable Applications for anti-WDPCP antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Function
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Cellular Location
Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9}
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(CB086 Antibody (C-term) (AAA286338) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CB086 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(CB086 Antibody (C-term) (AAA286338) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CB086 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(CB086 Antibody (C-term) (AAA286338) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CB086 antibody detected the CB086 protein (arrow).)
WB (Western Blot)
(CB086 Antibody (C-term) (AAA286338) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CB086 antibody detected the CB086 protein (arrow).)
Related Product Information for anti-WDPCP antibody
The C2ORF86 gene encodes an ortholog of Drosophila
'fritz,' a cytoplasmic WD40 repeat protein that controls planar
cell polarity (summarized by Kim et al., 2010 [PubMed
20671153]).
'fritz,' a cytoplasmic WD40 repeat protein that controls planar
cell polarity (summarized by Kim et al., 2010 [PubMed
20671153]).
Product Categories/Family for anti-WDPCP antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
85084
NCBI Official Full Name
WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 2
NCBI Official Synonym Full Names
WD repeat containing planar cell polarity effector
NCBI Official Symbol
WDPCP
NCBI Official Synonym Symbols
FRTZ; BBS15; FRITZ; CHDTHP; C2orf86
NCBI Protein Information
WD repeat-containing and planar cell polarity effector protein fritz homolog
UniProt Protein Name
WD repeat-containing and planar cell polarity effector protein fritz homolog
UniProt Gene Name
WDPCP
UniProt Synonym Gene Names
BBS15; C2orf86; FRITZ; hFRTZ
UniProt Entry Name
FRITZ_HUMAN
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Product Notes
The WDPCP wdpcp (Catalog #AAA286338) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 676-705. The CB086 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CB086 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the WDPCP wdpcp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CB086, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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