WB (Western Blot)
(CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).)
Rabbit anti-Human, mouse CBX8 Polyclonal Antibody | anti-CBX8 antibody
CBX8 Antibody (C-term)
Gene Names
CBX8; PC3; RC1
Reactivity
Human, mouse
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CBX8, Antibody; CBX8 Antibody (C-term); Chromobox protein homolog 8; Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1; CBX8; PC3; RC1; anti-CBX8 antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-337 amino acids from the C-terminal region of human CBX8.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
306-337
Sequence Length
389
Applicable Applications for anti-CBX8 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).)
WB (Western Blot)
(CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
WB (Western Blot)
(The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.)
WB (Western Blot)
(The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.)
Related Product Information for anti-CBX8 antibody
Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.
References
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43396
NCBI Official Full Name
chromobox protein homolog 8
NCBI Official Synonym Full Names
chromobox homolog 8
NCBI Official Symbol
CBX8
NCBI Official Synonym Symbols
PC3; RC1
NCBI Protein Information
chromobox protein homolog 8
UniProt Protein Name
Chromobox protein homolog 8
UniProt Gene Name
CBX8
UniProt Synonym Gene Names
PC3; RC1; Pc3; hPc3
UniProt Entry Name
CBX8_HUMAN
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Product Notes
The CBX8 cbx8 (Catalog #AAA288207) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 306-337. The CBX8 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CBX8 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CBX8 cbx8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CBX8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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