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IHC (Immunohistochemistry)
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Rabbit anti-Human CD276/B7-H3 Polyclonal Antibody | anti-CD276 antibody

CD276/B7-H3 Rabbit anti-Human Polyclonal Antibody

Gene Names
CD276; B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
CD276/B7-H3, Antibody; CD276/B7-H3 Rabbit anti-Human Polyclonal Antibody; PathPlus CD276/B7-H3 Antibody; CD276; 4Ig-B7-H3; B7 homolog 3; B7-H3; CD276 antigen; CD276 molecule; Costimulatory molecule; B7H3; B7RP-2; anti-CD276 antibody
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For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD276 antibody
Immunohistochemistry-Paraffin (IHC-P)
Target
Human CD276/B7-H3
Immunogen
LP-10685, synthetic peptide
Conjugation
Unconjugated
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistchemistry)

(CD276/B7-H3 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(CD276/B7-H3 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-CD276 antibody
B7-H3 antibody is an unconjugated rabbit polyclonal antibody to B7-H3 (CD276) from human. Validated for IHC.
CD276 (B7-H3) is a type I transmembrane protein and immune checkpoint inhibitor that is induced on antigen presenting cells. It plays a role in the inhibition of T-cell function. It is expressed constitutively on fibroblasts, endothelial cells, and osteoblasts. It is also induced on immune cells, particularly antigen-presenting dendritic cells, monocytes, NK cells, B cells, and some T-cells. It is overexpressed in a range of human cancers, including melanomas, leukemia, breast, prostate, ovarian, pancreatic, and colorectal cancers, while limited expression is seen in normal tissues. Overexpression of CD276 correlates with poor prognosis, suggesting that CD276 plays a role in immune evasion and tumorigenesis. It is a target for cancer immunotherapy and a candidate for inhibitory immune checkpoint blockade.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
57,165 Da
NCBI Official Full Name
CD276 antigen isoform b
NCBI Official Synonym Full Names
CD276 molecule
NCBI Official Symbol
CD276
NCBI Official Synonym Symbols
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
NCBI Protein Information
CD276 antigen; B7 homolog 3; costimulatory molecule
UniProt Protein Name
CD276 antigen
UniProt Gene Name
CD276
UniProt Synonym Gene Names
B7H3; B7-H3
UniProt Entry Name
CD276_HUMAN

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Product Notes

The CD276 cd276 (Catalog #AAA21341) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD276/B7-H3 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD276/B7-H3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). Researchers should empirically determine the suitability of the CD276 cd276 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD276/B7-H3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.