IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human spleen tissue using CD42c Polyclonal Antibody at dilution of 1:100.)
Rabbit CD42c Polyclonal Antibody | anti-CD42c antibody
CD42c Polyclonal Antibody
Gene Names
GP1BB; BS; CD42C; GPIBB; BDPLT1; GPIbbeta
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Affinity Purification
Synonyms
CD42c, Antibody; CD42c Polyclonal Antibody; Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c); anti-CD42c antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Concentration
1mg/mL (varies by lot)
Sequence Length
206
Applicable Applications for anti-CD42c antibody
ELISA, IHC (Immunohistochemistry)
Immunogen
Synthetic peptide from human protein
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human spleen tissue using CD42c Polyclonal Antibody at dilution of 1:100.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human spleen tissue using CD42c Polyclonal Antibody at dilution of 1:100.)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded Human spleen tissue using CD42c Polyclonal Antibody at dilution of 1:100.)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded Human spleen tissue using CD42c Polyclonal Antibody at dilution of 1:100.)
Related Product Information for anti-CD42c antibody
GP1BB (Glycoprotein Ib Platelet Beta Subunit) is a Protein Coding gene. Diseases associated with GP1BB include Bernard-Soulier Syndrome, Type C and Velocardiofacial Syndrome. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is GP9.Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,158 Da
NCBI Official Full Name
platelet glycoprotein Ib beta chain
NCBI Official Synonym Full Names
glycoprotein Ib platelet beta subunit
NCBI Official Symbol
GP1BB
NCBI Official Synonym Symbols
BS; CD42C; GPIBB; BDPLT1; GPIbbeta
NCBI Protein Information
platelet glycoprotein Ib beta chain
UniProt Protein Name
Platelet glycoprotein Ib beta chain
UniProt Gene Name
GP1BB
UniProt Synonym Gene Names
GP-Ib beta; GPIb-beta; GPIbB
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Product Notes
The CD42c gp1bb (Catalog #AAA173978) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD42c Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD42c can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CD42c gp1bb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD42c, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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