WB (Western Blot)
(CDKN1C Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow).)
Rabbit anti-Human, mouse CDKN1C Polyclonal Antibody | anti-CDKN1C antibody
CDKN1C Antibody (N-term)
Gene Names
CDKN1C; BWS; WBS; p57; BWCR; KIP2; p57Kip2
Reactivity
Human, mouse
Applications
Western Blot, ELISA, Immunofluorescence
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CDKN1C, Antibody; CDKN1C Antibody (N-term); Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2; CDKN1C; KIP2; anti-CDKN1C antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CDKN1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from the N-terminal region of human CDKN1C.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.3 (varies by lot)
Sequence Positions
34-64
Sequence Length
316
Applicable Applications for anti-CDKN1C antibody
WB (Western Blot), ELISA, IF (Immunofluorescence)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(CDKN1C Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow).)
WB (Western Blot)
(CDKN1C Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow).)
IF (Immunofluorescence)
(Fluorescent image of A549 cell stained with CDKN1C Antibody (N-term). A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CDKN1C primary antibody (1:25, 1 h at 37 degree). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree).CDKN1C immunoreactivity is localized to Nucleus significantly.)
IF (Immunofluorescence)
(Fluorescent image of A549 cell stained with CDKN1C Antibody (N-term). A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CDKN1C primary antibody (1:25, 1 h at 37 degree). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree).CDKN1C immunoreactivity is localized to Nucleus significantly.)
Related Product Information for anti-CDKN1C antibody
This gene is imprinted, with preferential expression of
the maternal allele. The encoded protein is a tight-binding, strong
inhibitor of several G1 cyclin/Cdk complexes and a negative
regulator of cell proliferation. Mutations in this gene are
implicated in sporadic cancers and Beckwith-Wiedemann syndorome,
suggesting that this gene is a tumor suppressor candidate. Three
transcript variants encoding two different isoforms have been found
for this gene.
the maternal allele. The encoded protein is a tight-binding, strong
inhibitor of several G1 cyclin/Cdk complexes and a negative
regulator of cell proliferation. Mutations in this gene are
implicated in sporadic cancers and Beckwith-Wiedemann syndorome,
suggesting that this gene is a tumor suppressor candidate. Three
transcript variants encoding two different isoforms have been found
for this gene.
Product Categories/Family for anti-CDKN1C antibody
References
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)
Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :
Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)
Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :
Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
32177
NCBI Official Full Name
cyclin-dependent kinase inhibitor 1C isoform a
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Official Symbol
CDKN1C
NCBI Official Synonym Symbols
BWS; WBS; p57; BWCR; KIP2; p57Kip2
NCBI Protein Information
cyclin-dependent kinase inhibitor 1C
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1C
UniProt Gene Name
CDKN1C
UniProt Synonym Gene Names
KIP2
UniProt Entry Name
CDN1C_HUMAN
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Product Notes
The CDKN1C cdkn1c (Catalog #AAA285808) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 34-64. The CDKN1C Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CDKN1C can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA, IF (Immunofluorescence). Researchers should empirically determine the suitability of the CDKN1C cdkn1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDKN1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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