IHC (Immunohiostchemistry)
(CDKN2C Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CDKN2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human CDKN2C Polyclonal Antibody | anti-CDKN2C antibody
CDKN2C Antibody (C-term)
Gene Names
CDKN2C; p18; INK4C; p18-INK4C
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CDKN2C, Antibody; CDKN2C Antibody (C-term); Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6; anti-CDKN2C antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.27 (varies by lot)
Sequence Positions
113-139
Sequence Length
168
Applicable Applications for anti-CDKN2C antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(CDKN2C Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CDKN2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(CDKN2C Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CDKN2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of CDKN2C (arrow) using rabbit polyclonal CDKN2C Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CDKN2C gene.)
WB (Western Blot)
(Western blot analysis of CDKN2C (arrow) using rabbit polyclonal CDKN2C Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CDKN2C gene.)
Related Product Information for anti-CDKN2C antibody
The protein encoded by this gene is a member of the INK4
family of cyclin-dependent kinase inhibitors. This protein has been
shown to interact with CDK4 or CDK6, and prevent the activation of
the CDK kinases, thus function as a cell growth regulator that
controls cell cycle G1 progression. Ectopic expression of this gene
was shown to suppress the growth of human cells in a manner that
appears to correlate with the presence of a wild-type RB1 function.
Studies in the knockout mice suggested the roles of this gene in
regulating spermatogenesis, as well as in suppressing
tumorigenesis. Two alternatively spliced transcript variants of
this gene, which encode an identical protein, have been reported.
family of cyclin-dependent kinase inhibitors. This protein has been
shown to interact with CDK4 or CDK6, and prevent the activation of
the CDK kinases, thus function as a cell growth regulator that
controls cell cycle G1 progression. Ectopic expression of this gene
was shown to suppress the growth of human cells in a manner that
appears to correlate with the presence of a wild-type RB1 function.
Studies in the knockout mice suggested the roles of this gene in
regulating spermatogenesis, as well as in suppressing
tumorigenesis. Two alternatively spliced transcript variants of
this gene, which encode an identical protein, have been reported.
Product Categories/Family for anti-CDKN2C antibody
References
Stratakis, C., et al. Clin. Genet. 78(5):457-463(2010)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)
Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)
Hossain, M.G., et al. Endocr. Pathol. 20(2):114-121(2009)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)
Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)
Hossain, M.G., et al. Endocr. Pathol. 20(2):114-121(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18127
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor C
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NCBI Official Symbol
CDKN2C
NCBI Official Synonym Symbols
p18; INK4C; p18-INK4C
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor C
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor C
UniProt Gene Name
CDKN2C
UniProt Synonym Gene Names
CDKN6
UniProt Entry Name
CDN2C_HUMAN
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Product Notes
The CDKN2C cdkn2c (Catalog #AAA288353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 113-139. The CDKN2C Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDKN2C can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CDKN2C cdkn2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDKN2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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