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WB (Western Blot)
(Western blot analysis of anti-CSE1L Pab in, from left to right, A375, CEM, and mouse heart cell line lysates (35ug/lane). CSE1L(arrow) was detected using the purified Pab.)
Rabbit Cellular Apoptosis Susceptibility Polyclonal Antibody | anti-CSE1L antibody
Cellular Apoptosis Susceptibility Antibody (N-term)
Gene Names
CSE1L; CAS; CSE1; XPO2
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Zebrafish)
Applications
Immunohistochemistry, Immunofluorescence, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Cellular Apoptosis Susceptibility, Antibody; Cellular Apoptosis Susceptibility Antibody (N-term); Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter; CSE1L; CAS; XPO2; anti-CSE1L antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Zebrafish)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Cellular Apoptosis Susceptibility antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human Cellular Apoptosis Susceptibility.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
55-84
Sequence Length
915
Applicable Applications for anti-CSE1L antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Crown Antibody
Yes
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Western blot analysis of anti-CSE1L Pab in, from left to right, A375, CEM, and mouse heart cell line lysates (35ug/lane). CSE1L(arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-CSE1L Pab in, from left to right, A375, CEM, and mouse heart cell line lysates (35ug/lane). CSE1L(arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of lysates from Hela, Jurkat, Ramos, mouse NIH/3T3 cell line (from left to right), using CSE1L Antibody. AAA283781 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
WB (Western Blot)
(Western blot analysis of lysates from Hela, Jurkat, Ramos, mouse NIH/3T3 cell line (from left to right), using CSE1L Antibody. AAA283781 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
IHC (Immunohistochemisry)
(Immunohistochemical analysis of paraffin-embedded H. tonsil section using CSE1L Antibody. AAA283781 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.)
IHC (Immunohistochemisry)
(Immunohistochemical analysis of paraffin-embedded H. tonsil section using CSE1L Antibody. AAA283781 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded H. stomach section using CSE1L Antibody. AAA283781 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded H. stomach section using CSE1L Antibody. AAA283781 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.)
IF (Immunofluorescence)
(Fluorescent image of HeLa cells stained with Cellular Apoptosis Susceptibility Antibody (N-term). AAA283781 was diluted at 1:100 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor 555 conjugated with Phalloidin (red).)
IF (Immunofluorescence)
(Fluorescent image of HeLa cells stained with Cellular Apoptosis Susceptibility Antibody (N-term). AAA283781 was diluted at 1:100 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor 555 conjugated with Phalloidin (red).)
Related Product Information for anti-CSE1L antibody
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
Product Categories/Family for anti-CSE1L antibody
References
Goldberg, G.S., et al., J. Biol. Chem. 278(47):46533-46540 (2003).
Behrens, P., et al., Apoptosis 8(1):39-44 (2003).
Jiang, M.C., et al., Biochem. Biophys. Res. Commun. 294(4):900-905 (2002).
Wellmann, A., et al., Int. J. Mol. Med. 7(5):489-494 (2001).
Brinkmann, U., et al., Genomics 58(1):41-49 (1999).
Behrens, P., et al., Apoptosis 8(1):39-44 (2003).
Jiang, M.C., et al., Biochem. Biophys. Res. Commun. 294(4):900-905 (2002).
Wellmann, A., et al., Int. J. Mol. Med. 7(5):489-494 (2001).
Brinkmann, U., et al., Genomics 58(1):41-49 (1999).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
110417
NCBI Official Full Name
exportin-2 isoform 2
NCBI Official Synonym Full Names
CSE1 chromosome segregation 1-like (yeast)
NCBI Official Symbol
CSE1L
NCBI Official Synonym Symbols
CAS; CSE1; XPO2
NCBI Protein Information
exportin-2
UniProt Protein Name
Exportin-2
UniProt Gene Name
CSE1L
UniProt Synonym Gene Names
CAS; XPO2; Exp2
UniProt Entry Name
XPO2_HUMAN
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Product Notes
The CSE1L cse1l (Catalog #AAA283781) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 55-84. The Cellular Apoptosis Susceptibility Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Bovine, Zebrafish) and may cross-react with other species as described in the data sheet. AAA Biotech's Cellular Apoptosis Susceptibility can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CSE1L cse1l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cellular Apoptosis Susceptibility, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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