Rabbit CHMP1A Polyclonal Antibody | anti-CHMP1A antibody

CHMP1A Antibody

Cat. Num. AAA328808

• Gene Names: CHMP1A; PCH8; CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1
• Reactivity: Human, Mouse; Predicted: Pig, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CHMP1A, Antibody; CHMP1A Antibody; Charged multivesicular body protein 1a; CHM1A_HUMAN; CHMP1a; Chromatin modifying protein 1a; Chromatin-modifying protein 1a; hVps46 1; hVps46-1; KIAA0047; Metalloprotease 1; PCOLN3; Procollagen (type III) N endopeptidase; PRSM1; Vacuolar protein sorting 46 1; Vacuolar protein sorting-associated protein 46-1; Vps46 1; Vps46-1; anti-CHMP1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse; Predicted: Pig, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CHMP1A Antibody detects endogenous levels of CHMP1A.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 332

• Applicable Applications for anti-CHMP1A antibody: WB (Western Blot)
• Immunogen: A synthesized peptide derived from human CHMP1A.
• Tissue Specificity: Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Endosome; Nucleus
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

WB (Western Blot)

(Western blot analysis of extracts from Hela cells, using CHMP1A Antibody. The lane on the left was treated with blocking peptide.)

WB (Western Blot)

(Western blot analysis of extracts from A431 cells, using CHMP1A Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-CHMP1A antibody

Description: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Subunit Structure: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1.

Similarity: Belongs to the SNF7 family.

NCBI and Uniprot Product Information

• NCBI GI #: 119587121
• NCBI GeneID: 5119
• UniProt Accession #: Q9HD42
• Molecular Weight: Observed: 25 kDa; Predicted: 22 kDa
• NCBI Official Full Name: procollagen (type III) N-endopeptidase, isoform CRA_a, partial
• NCBI Official Synonym Full Names: charged multivesicular body protein 1A
• NCBI Official Symbol: CHMP1A
• NCBI Official Synonym Symbols: PCH8; CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1
• NCBI Protein Information: charged multivesicular body protein 1a
• UniProt Protein Name: Charged multivesicular body protein 1a
• UniProt Gene Name: CHMP1A
• UniProt Synonym Gene Names: CHMP1; KIAA0047; PCOLN3; PRSM1; CHMP1a; Vps46-1; hVps46-1
• UniProt Entry Name: CHM1A_HUMAN