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IHC (Immunohistochemistry)
(Anti-CHRM2 / M2 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit CHRM2 / M2 Polyclonal Antibody | anti-CHRM2 antibody
Rabbit Polyclonal to Human CHRM2 / M2
Gene Names
CHRM2; HM2
Reactivity
Gibbon, Bovine, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, SheepPredicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
CHRM2 / M2, Antibody; Rabbit Polyclonal to Human CHRM2 / M2; Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) IHC-plus; CHRM2; 7TM receptor; HM2; M2 muscarinic receptor; M2-mAChR; Muscarinic receptor M2; Muscarinic M2 receptor; Human CHRM2; M2; anti-CHRM2 antibody
Host
Rabbit
Reactivity
Gibbon, Bovine, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Sheep
Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
466
Applicable Applications for anti-CHRM2 antibody
IHC (Immunohistochemistry)
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CHRM2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Sheep, Dog, Bovine, Hamster, Elephant.
Immunogen Type
Synthetic peptide
Immunogen
CHRM2 / M2 antibody was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CHRM2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Sheep, Dog, Bovine, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Guinea pig (100%); Bat, Opossum, Turkey, Chicken (94%); Xenopus (88%); Platypus, Zebrafish, Stickleback (81%).
Antigen Modification
Cytoplasmic Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
IHC (Immunohistochemistry)
(Anti-CHRM2 / M2 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemistry)
(Anti-CHRM2 / M2 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemisry)
(Anti-CHRM2 / M2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemisry)
(Anti-CHRM2 / M2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohiostchemistry)
(Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohiostchemistry)
(Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemistry)
(Anti-CHRM2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemistry)
(Anti-CHRM2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-CHRM2 antibody
Muscarinic cholinergic receptor 2, an Acetylcholine Receptor, has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women.
Product Categories/Family for anti-CHRM2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,715 Da
NCBI Official Full Name
muscarinic acetylcholine receptor M2
NCBI Official Synonym Full Names
cholinergic receptor, muscarinic 2
NCBI Official Symbol
CHRM2
NCBI Official Synonym Symbols
HM2
NCBI Protein Information
muscarinic acetylcholine receptor M2; 7TM receptor; muscarinic M2 receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a
UniProt Protein Name
Muscarinic acetylcholine receptor M2
UniProt Gene Name
CHRM2
UniProt Entry Name
ACM2_HUMAN
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Product Notes
The CHRM2 chrm2 (Catalog #AAA51561) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human CHRM2 / M2 reacts with Gibbon, Bovine, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Sheep Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's CHRM2 / M2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CHRM2 chrm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHRM2 / M2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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