IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CLCN7 Antibody (C-term) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit CLCN7 Polyclonal Antibody | anti-CLCN7 antibody
CLCN7 Antibody (C-term)
Gene Names
CLCN7; CLC7; CLC-7; OPTA2; OPTB4; PPP1R63
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Rat)
Applications
Immunofluorescence, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CLCN7, Antibody; CLCN7 Antibody (C-term); H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7; CLCN7; anti-CLCN7 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CLCN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-720 amino acids from the C-terminal region of human CLCN7.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
692-720
Sequence Length
781
Applicable Applications for anti-CLCN7 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CLCN7 Antibody (C-term) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CLCN7 Antibody (C-term) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohiostchemistry)
(CLCN7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLCN7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(CLCN7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLCN7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(CLCN7 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CLCN7 antibody detected the CLCN7 protein (arrow).)
WB (Western Blot)
(CLCN7 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CLCN7 antibody detected the CLCN7 protein (arrow).)
Related Product Information for anti-CLCN7 antibody
The product of this gene belongs to the CLC chloride
channel family of proteins. Chloride channels play important roles
in the plasma membrane and in intracellular organelles. This gene
encodes chloride channel 7. Defects in this gene are the cause of
osteopetrosis autosomal recessive type 4 (OPTB4), also called
infantile malignant osteopetrosis type 2 as well as the cause of
autosomal dominant osteopetrosis type 2 (OPTA2), also called
autosomal dominant Albers-Schonberg disease or marble disease
autosoml dominant. Osteopetrosis is a rare genetic disease
characterized by abnormally dense bone, due to defective resorption
of immature bone. OPTA2 is the most common form of osteopetrosis,
occurring in adolescence or adulthood.
channel family of proteins. Chloride channels play important roles
in the plasma membrane and in intracellular organelles. This gene
encodes chloride channel 7. Defects in this gene are the cause of
osteopetrosis autosomal recessive type 4 (OPTB4), also called
infantile malignant osteopetrosis type 2 as well as the cause of
autosomal dominant osteopetrosis type 2 (OPTA2), also called
autosomal dominant Albers-Schonberg disease or marble disease
autosoml dominant. Osteopetrosis is a rare genetic disease
characterized by abnormally dense bone, due to defective resorption
of immature bone. OPTA2 is the most common form of osteopetrosis,
occurring in adolescence or adulthood.
Product Categories/Family for anti-CLCN7 antibody
References
Furthner, D., et al. Klin Padiatr 222(3):180-183(2010)
Phadke, S.R., et al. Indian J. Med. Res. 131, 508-514 (2010) :
Pangrazio, A., et al. Hum. Mutat. 31 (1), E1071-E1080 (2010) :
Kajiya, H., et al. Pflugers Arch. 458(6):1049-1059(2009)
Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)
Phadke, S.R., et al. Indian J. Med. Res. 131, 508-514 (2010) :
Pangrazio, A., et al. Hum. Mutat. 31 (1), E1071-E1080 (2010) :
Kajiya, H., et al. Pflugers Arch. 458(6):1049-1059(2009)
Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
88679
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 7 isoform b
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive 7
NCBI Official Symbol
CLCN7
NCBI Official Synonym Symbols
CLC7; CLC-7; OPTA2; OPTB4; PPP1R63
NCBI Protein Information
H(+)/Cl(-) exchange transporter 7
UniProt Protein Name
H(+)/Cl(-) exchange transporter 7
UniProt Gene Name
CLCN7
UniProt Synonym Gene Names
ClC-7
UniProt Entry Name
CLCN7_HUMAN
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Product Notes
The CLCN7 clcn7 (Catalog #AAA287778) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 692-720. The CLCN7 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CLCN7 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CLCN7 clcn7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCN7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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